4-(4-(benzyloxy)phenyl)-2-hydroxybutanenitrile

Base Information

Chemical Name:4-(4-(benzyloxy)phenyl)-2-hydroxybutanenitrile
CAS No.:945414-34-6
Molecular Formula:C₁₇H₁₇NO₂
Molecular Weight:267.327
Hs Code.:

Synonyms:4-(4-(benzyloxy)phenyl)-2-hydroxybutanenitrile

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Chemical Property of 4-(4-(benzyloxy)phenyl)-2-hydroxybutanenitrile

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Technology Process of 4-(4-(benzyloxy)phenyl)-2-hydroxybutanenitrile

There total 5 articles about 4-(4-(benzyloxy)phenyl)-2-hydroxybutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 151-50-8
potassium cyanide

: 68486-77-1
3-(4-(benzyloxy)phenyl)propanal

: 945414-34-6
4-(4-(benzyloxy)phenyl)-2-hydroxybutanenitrile

Guidance literature:: In tetrahydrofuran; water; at 25 ℃; for 50h;
DOI:10.1021/jm061414r

Reference yield:

: 7400-08-0,50940-26-6
p-Coumaric Acid

: 945414-34-6
4-(4-(benzyloxy)phenyl)-2-hydroxybutanenitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: 99 percent / H₂ / Pd/C / ethyl acetate / 20 °C

2.1: NaH / dimethylformamide / 0.17 h / 0 °C

2.2: 72 percent / dimethylformamide / 20 °C

3.1: methanol / 16 h / 25 °C

4.1: 1.0 g / DIBAL-H / toluene / 0.75 h

5.1: 84 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 1.5 h / -78 - 25 °C

6.1: 96 percent / tetrahydrofuran; H₂O / 50 h / 25 °C

With oxalyl dichloride; hydrogen; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm061414r

Reference yield:

: 501-97-3
4-hydroxyphenylpropionic acid

: 945414-34-6
4-(4-(benzyloxy)phenyl)-2-hydroxybutanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide / 0.17 h / 0 °C

1.2: 72 percent / dimethylformamide / 20 °C

2.1: methanol / 16 h / 25 °C

3.1: 1.0 g / DIBAL-H / toluene / 0.75 h

4.1: 84 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 1.5 h / -78 - 25 °C

5.1: 96 percent / tetrahydrofuran; H₂O / 50 h / 25 °C

With oxalyl dichloride; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm061414r