6-N-acetyl-2',3'-di-O-benzoyl-5'-O-tert-butyldimethylsilyl-8-oxoadenosine

Base Information

• Chemical Name: 6-N-acetyl-2',3'-di-O-benzoyl-5'-O-tert-butyldimethylsilyl-8-oxoadenosine
• CAS No.: 297731-13-6
• Molecular Formula: C₃₂H₃₇N₅O₈Si
• Molecular Weight: 647.76
• Mol file: 297731-13-6.mol

Synonyms:6-N-acetyl-2',3'-di-O-benzoyl-5'-O-tert-butyldimethylsilyl-8-oxoadenosine

Chemical Property of 6-N-acetyl-2',3'-di-O-benzoyl-5'-O-tert-butyldimethylsilyl-8-oxoadenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-N-acetyl-2',3'-di-O-benzoyl-5'-O-tert-butyldimethylsilyl-8-oxoadenosine

There total 6 articles about 6-N-acetyl-2',3'-di-O-benzoyl-5'-O-tert-butyldimethylsilyl-8-oxoadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

benzoic acid anhydride (93-97-0) + 6-N-acetyl-5'-O-tert-butyldimethylsilyl-8-oxoadenosine (297731-12-5) → 6-N-acetyl-2',3'-di-O-benzoyl-5'-O-tert-butyldimethylsilyl-8-oxoadenosine (297731-13-6)

Guidance literature:

With pyridine; dmap; at 20 ℃; for 4h;

DOI:10.1016/S0040-4039(00)00926-6

Reference yield:

6-N-acetyl-8-oxoadenosine (3868-35-7) → 6-N-acetyl-2',3'-di-O-benzoyl-5'-O-tert-butyldimethylsilyl-8-oxoadenosine (297731-13-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / pyridine / 12 h / 20 °C

2: 87 percent / 4-(N,N-dimethylamino)pyridine / pyridine / 3 h / 20 °C

With pyridine; dmap; In pyridine;

DOI:10.1021/jo016176g

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 6-N-acetyl-2',3'-di-O-benzoyl-5'-O-tert-butyldimethylsilyl-8-oxoadenosine (297731-13-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / pyridine / 12 h / 20 °C

2: 87 percent / 4-(N,N-dimethylamino)pyridine / pyridine / 3 h / 20 °C

With pyridine; dmap; In pyridine;

DOI:10.1021/jo016176g

upstream raw materials:

benzoic acid anhydride

6-N-acetyl-5'-O-tert-butyldimethylsilyl-8-oxoadenosine

6-N-acetyl-8-oxoadenosine

tert-butyldimethylsilyl chloride

Downstream raw materials:

6-N-acetyl-2',3'-di-O-benzoyl-8-oxoadenosine