(4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl)methanol

Base Information

• Chemical Name: (4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl)methanol
• CAS No.: 1168207-69-9
• Molecular Formula: C₁₃H₁₆ClNO₂
• Molecular Weight: 253.729
• Mol file: 1168207-69-9.mol

Synonyms:(4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl)methanol

Chemical Property of (4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl)methanol

There total 2 articles about (4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-(4-chlorophenyl)-6,6-dimethyl-3-((trimethylsilyloxy)methyl)-5,6-dihydro-4H-1,2-oxazine (1168207-56-4) → (4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl)methanol (1168207-69-9)

Guidance literature:

With ammonium fluoride-hydrogen fluoride; In methanol; at 20 ℃; for 24h;

DOI:10.1016/j.tet.2009.03.082

Reference yield: 76.0%

C16H24ClNO2Si (1168207-46-2) + trifluoroacetic anhydride (407-25-0) → (4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl)methanol (1168207-69-9)

Guidance literature:

C₁₆H₂₄ClNO₂Si; trifluoroacetic anhydride; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

With methanol; potassium carbonate; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1055/s-0029-1216907

Reference yield: 100.0%

chloro-trimethyl-silane (75-77-4) + (4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl)methanol (1168207-69-9) → 4-(4-chlorophenyl)-6,6-dimethyl-3-((trimethylsilyloxy)methyl)-5,6-dihydro-4H-1,2-oxazine (1168207-56-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2009.03.082

upstream raw materials:

4-(4-chlorophenyl)-6,6-dimethyl-3-((trimethylsilyloxy)methyl)-5,6-dihydro-4H-1,2-oxazine

C₁₆H₂₄ClNO₂Si

trifluoroacetic anhydride

Downstream raw materials:

4-(4-chlorophenyl)-6,6-dimethyl-3-((trimethylsilyloxy)methyl)-5,6-dihydro-4H-1,2-oxazine