benzyl 6-ethyl-4-(3-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

Chemical Name:benzyl 6-ethyl-4-(3-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS No.:1224680-11-8
Molecular Formula:C₂₀H₂₀N₂O₄
Molecular Weight:352.39
Hs Code.:

Synonyms:benzyl 6-ethyl-4-(3-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Chemical Property of benzyl 6-ethyl-4-(3-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Technology Process of benzyl 6-ethyl-4-(3-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 1 articles about benzyl 6-ethyl-4-(3-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 4949-45-5
benzyl 2-methylacetoacetate

: 100-83-4
meta-hydroxybenzaldehyde

: 57-13-6
urea

: 1224680-11-8
benzyl 6-ethyl-4-(3-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: ytterbium(III) triflate; In tetrahydrofuran; at 90 ℃; for 24h; Inert atmosphere;

Reference yield: 100.0%

: 1224680-11-8
benzyl 6-ethyl-4-(3-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1224680-12-9
C₂₆H₃₄N₂O₄Si

Guidance literature:: With 1H-imidazole; N,N-dimethyl-formamide; at 25 ℃;

Reference yield:

: 1224680-11-8
benzyl 6-ethyl-4-(3-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1365386-49-7
cyclohexylmethyl 6-ethyl-4-(3-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 25 °C

2.1: palladium 10% on activated carbon; hydrogen; triethylamine / methanol / 3 h / 25 °C / 2250.23 Torr

2.2: pH 2

3.1: methanol / -20 - 76 °C

4.1: hydrogenchloride / water / pH 2

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran; dichloromethane / 0.17 h / 0 °C

With 1H-imidazole; hydrogenchloride; dmap; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.12.090