(Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Base Information

Chemical Name:(Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate
CAS No.:1354823-59-8
Molecular Formula:C₂₅H₃₁N₆O₈P
Molecular Weight:574.53
Hs Code.:

(Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Synonyms:(Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

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Chemical Property of (Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

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Technology Process of (Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

There total 12 articles about (Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1256490-31-9
(S)-2-[(S)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester

: 1191237-49-6
1′-cyano-2′-C-methyl-4-aza-7,9-dideazaadenosine

: 1354823-59-8
(Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Guidance literature:: 1′-cyano-2′-C-methyl-4-aza-7,9-dideazaadenosine; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

With tert-butylmagnesium chloride; In tetrahydrofuran; for 0.166667h;

(S)-2-[(S)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester; In tetrahydrofuran; at 50 ℃;

Reference yield:

: 1256490-48-8
(S)-2-[(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester

: 1354823-59-8
(Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Chiralpak IC / isopropyl alcohol; n-heptane / Resolution of racemate

2.1: tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

2.2: 0.17 h

2.3: 50 °C

With Chiralpak IC; In tetrahydrofuran; n-heptane; isopropyl alcohol;

Reference yield:

: 2′,3′,5′-O-tribenzyl-1′-hydroxy-2′-C-methyl-4-aza-7,9-dideazaadenosine

: 1354823-59-8
(Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trimethylsilyl cyanide; boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 20 °C

2.1: boron trichloride / dichloromethane / 1 h / -78 °C

2.2: -78 - 20 °C

3.1: tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

3.2: 0.17 h

3.3: 50 °C

With trimethylsilyl cyanide; boron trifluoride diethyl etherate; boron trichloride; In tetrahydrofuran; dichloromethane;