2-{2-[(pyrrolidine-2-carbonyl)-amino]benzoylamino}benzoic acid methyl ester

Base Information

Chemical Name:2-{2-[(pyrrolidine-2-carbonyl)-amino]benzoylamino}benzoic acid methyl ester
CAS No.:1129527-34-9
Molecular Formula:C₂₀H₂₁N₃O₄
Molecular Weight:367.404
Hs Code.:

Synonyms:2-{2-[(pyrrolidine-2-carbonyl)-amino]benzoylamino}benzoic acid methyl ester

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Chemical Property of 2-{2-[(pyrrolidine-2-carbonyl)-amino]benzoylamino}benzoic acid methyl ester

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Technology Process of 2-{2-[(pyrrolidine-2-carbonyl)-amino]benzoylamino}benzoic acid methyl ester

There total 8 articles about 2-{2-[(pyrrolidine-2-carbonyl)-amino]benzoylamino}benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 2-[2-(2-methoxycarbonylphenylcarbamoyl)phenylcarbamoyl]pyrrolidine-1-carboxylic acid tert-butyl ester

: 1129527-34-9
2-{2-[(pyrrolidine-2-carbonyl)-amino]benzoylamino}benzoic acid methyl ester

Guidance literature:: With iodine; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1055/s-0029-1218606

Reference yield:

: 1129527-29-2
Cbz-Pro-Abz-Abz-OMe

: 1129527-34-9
2-{2-[(pyrrolidine-2-carbonyl)-amino]benzoylamino}benzoic acid methyl ester

Guidance literature:: With palladium hydroxide on carbon; hydrogen; In methanol; at 20 ℃;
DOI:10.1039/b813880j

Reference yield:

: 610-14-0
2-nitrobenzyl chloride

: 1129527-34-9
2-{2-[(pyrrolidine-2-carbonyl)-amino]benzoylamino}benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane

2: palladium(II) hydroxide; methanol / 4 h

3: tetrahydrofuran / 9 h / 0 - 70 °C

4: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With methanol; palladium(II) hydroxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja405455g