methyl 2-(2-((S)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamido) benzamido)benzoate

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Chemical Name:methyl 2-(2-((S)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamido) benzamido)benzoate
CAS No.:1448441-16-4
Molecular Formula:C₄₄H₄₆N₆O₈
Molecular Weight:786.885
Hs Code.:

Synonyms:methyl 2-(2-((S)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamido) benzamido)benzoate

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Chemical Property of methyl 2-(2-((S)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamido) benzamido)benzoate

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Technology Process of methyl 2-(2-((S)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamido) benzamido)benzoate

There total 8 articles about methyl 2-(2-((S)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamido) benzamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1129527-34-9
2-{2-[(pyrrolidine-2-carbonyl)-amino]benzoylamino}benzoic acid methyl ester

: 1448441-15-3
(S)-N-(2-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)phenyl)-1-pivaloylpyrrolidine-2-carboxamide

: 1448441-16-4
methyl 2-(2-((S)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamido) benzamido)benzoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 0 ℃; for 2h; Molecular sieve;
DOI:10.1021/ja405455g

Reference yield:

: 134-20-3
2-carbomethoxyaniline

: 1448441-16-4
methyl 2-(2-((S)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamido) benzamido)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane

2: palladium(II) hydroxide; methanol / 4 h

3: tetrahydrofuran / 9 h / 0 - 70 °C

4: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 0 °C / Molecular sieve

With methanol; palladium(II) hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja405455g

Reference yield:

: (S)-N-(tert-Butoxycarbonyl)proline ethyl carbonate

: 1448441-16-4
methyl 2-(2-((S)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamido) benzamido)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 9 h / 0 - 70 °C

2: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 0 °C / Molecular sieve

With 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja405455g