(S)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamide

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Chemical Name:(S)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamide
CAS No.:1448441-09-5
Molecular Formula:C₄₄H₄₇N₇O₇
Molecular Weight:785.9
Hs Code.:

(S)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamide

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Chemical Property of (S)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamide

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Technology Process of (S)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamide

There total 12 articles about (S)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1448441-16-4
methyl 2-(2-((S)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamido) benzamido)benzoate

: 74-89-5
methylamine

: 1448441-09-5
(S)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamide

Guidance literature:: In methanol; at 20 ℃;
DOI:10.1021/ja405455g

Reference yield:

: 134-20-3
2-carbomethoxyaniline

: 1448441-09-5
(S)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane

2: palladium(II) hydroxide; methanol / 4 h

3: tetrahydrofuran / 9 h / 0 - 70 °C

4: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 0 °C / Molecular sieve

6: methanol / 20 °C

With methanol; palladium(II) hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja405455g

Reference yield:

: (S)-N-(tert-Butoxycarbonyl)proline ethyl carbonate

: 1448441-09-5
(S)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 9 h / 0 - 70 °C

2: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 0 °C / Molecular sieve

4: methanol / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja405455g