(E)-6-(1,3-Dihydro-4,6-diMethoxy-7-Methyl-3-oxo-5-isobenzofuranyl)-4-Methyl-4-hexenoic Acid

Base Information

Chemical Name:(E)-6-(1,3-Dihydro-4,6-diMethoxy-7-Methyl-3-oxo-5-isobenzofuranyl)-4-Methyl-4-hexenoic Acid
CAS No.:38877-93-9
Molecular Formula:C₁₈H₂₂O₆
Molecular Weight:334.369
Hs Code.:
Mol file:38877-93-9.mol

Synonyms:7-O-Methylmycophenolic acid

Suppliers and Price of (E)-6-(1,3-Dihydro-4,6-diMethoxy-7-Methyl-3-oxo-5-isobenzofuranyl)-4-Methyl-4-hexenoic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(E)-6-(1,3-Dihydro-4,6-dimethoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoicAcid
25mg
$ 120.00

TRC
(E)-6-(1,3-Dihydro-4,6-dimethoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoicAcid
500mg
$ 2120.00

TRC
(E)-6-(1,3-Dihydro-4,6-dimethoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoicAcid
50mg
$ 240.00

Matrix Scientific
(4E)-6-(4,6-Dimethoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
1g
$ 150.00

Matrix Scientific
(4E)-6-(4,6-Dimethoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
0.500g
$ 120.00

Total 9 raw suppliers

Chemical Property of (E)-6-(1,3-Dihydro-4,6-diMethoxy-7-Methyl-3-oxo-5-isobenzofuranyl)-4-Methyl-4-hexenoic Acid

Chemical Property:

Boiling Point:583.1±50.0 °C(Predicted)
PKA:4.71±0.10(Predicted)
Density:1?+-.0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

(E)-6-(1,3-Dihydro-4,6-dimethoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (E)-6-(1,3-Dihydro-4,6-dimethoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic Acid, is the Dimethoxy analogue of Mycophenolic Acid (M831500), which is an immunosuppressant drug used to prevent rejection in organ transplantation. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides.

Technology Process of (E)-6-(1,3-Dihydro-4,6-diMethoxy-7-Methyl-3-oxo-5-isobenzofuranyl)-4-Methyl-4-hexenoic Acid

There total 11 articles about (E)-6-(1,3-Dihydro-4,6-diMethoxy-7-Methyl-3-oxo-5-isobenzofuranyl)-4-Methyl-4-hexenoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 60435-90-7
5,7-dimethoxy-6-(5-methoxycarbonyl-3-methyl-2-pentenyl)-4-methylphthalide

: 38877-93-9
7-O-Methylmycophenolic acid

Guidance literature:: With lithium hydroxide; In acetone; for 2h;
DOI:10.1016/j.bmcl.2007.06.059

Reference yield:

: 545392-47-0
(E)-6-(4,6-Dimethoxy-7-methyl-3-oxo-1,3-dihydro-isobenzofuran-5-yl)-4-methyl-hex-4-enal

: 38877-93-9
7-O-Methylmycophenolic acid

Guidance literature:: With chromium(VI) oxide; In acetone; at -30 ℃;
DOI:10.1016/S0040-4039(98)00423-7

Reference yield:

: 207398-37-6
6-((E)-3,7-Dimethyl-octa-2,6-dienyl)-5,7-dimethoxy-4-methyl-3H-isobenzofuran-1-one

: 38877-93-9
7-O-Methylmycophenolic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: O₃ / methanol / -78 °C

1.2: Me₂S / methanol / 3 h / -10 - 20 °C

2.1: Jones reagent / acetone / 4 h / -30 °C

With jones reagent; ozone; In methanol; acetone;
DOI:10.1016/S0040-4020(03)00102-9