5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide

Base Information

Chemical Name:5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide
CAS No.:1451994-10-7
Molecular Formula:C₁₇H₁₇FN₄O₂S
Molecular Weight:360.412
Hs Code.:

Synonyms:5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide

Suppliers and Price of 5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide

There total 6 articles about 5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 123652-95-9
1-(3-fluoro-4-methoxyphenyl)methanamine

: 1452226-14-0
5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid

: 1451994-10-7
5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide

Guidance literature:: 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

1-(3-fluoro-4-methoxyphenyl)methanamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1002/cmdc.201800710

Reference yield: 66.0%

: 123652-95-9
1-(3-fluoro-4-methoxyphenyl)methanamine

: 1451998-17-6
sodium 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylate

: 1451994-10-7
5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide

Guidance literature:: sodium 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylate; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h; Inert atmosphere;

1-(3-fluoro-4-methoxyphenyl)methanamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.6b00461

Reference yield:

: 93824-72-7
3-chloro-5,6-dimethylpyridazine-4-carbonitrile

: 1451994-10-7
5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol; water / 0.5 h / 150 °C / Microwave irradiation; Inert atmosphere

2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; dichloromethane / 0.08 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.6b00461