2,3,4,9-tetrahydro-1-(4-methoxyphenyl)-2-tosyl-1H-pyrido[3,4-b]indole

Base Information

• Chemical Name: 2,3,4,9-tetrahydro-1-(4-methoxyphenyl)-2-tosyl-1H-pyrido[3,4-b]indole
• CAS No.: 296797-76-7
• Molecular Formula: C₂₅H₂₄N₂O₃S
• Molecular Weight: 432.543
• Mol file: 296797-76-7.mol

Synonyms:2,3,4,9-tetrahydro-1-(4-methoxyphenyl)-2-tosyl-1H-pyrido[3,4-b]indole

Chemical Property of 2,3,4,9-tetrahydro-1-(4-methoxyphenyl)-2-tosyl-1H-pyrido[3,4-b]indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,4,9-tetrahydro-1-(4-methoxyphenyl)-2-tosyl-1H-pyrido[3,4-b]indole

There total 4 articles about 2,3,4,9-tetrahydro-1-(4-methoxyphenyl)-2-tosyl-1H-pyrido[3,4-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

2,5-dihydro-2-(4-methoxyphenyl)-1-tosyl-1H-pyrrole + carbon monoxide (201230-82-2) + phenylhydrazine (100-63-0) → 2,3,4,9-tetrahydro-1-(4-methoxyphenyl)-2-tosyl-1H-pyrido[3,4-b]indole (296797-76-7) + 2,3,4,9-tetrahydro-3-phenyl-2-tosyl-1H-pyrido[3,4-b]indole

Guidance literature:

2,5-dihydro-2-(4-methoxyphenyl)-1-tosyl-1H-pyrrole; carbon monoxide; phenylhydrazine; With Rh(acac)2(CO)2; hydrogen; triphenylphosphine; In tetrahydrofuran; at 100 ℃; for 72h; Autoclave;

With sulfuric acid; In tetrahydrofuran; for 3h; optical yield given as %ee; Reflux;

DOI:10.1021/ol801071y

Reference yield:

p-toluenesulfonyl chloride (98-59-9) + 1-(4-methoxyphenyl)-1,2,3,4-tetrahydro-1H-pyrido[3,4-b]indole (3380-73-2,121998-75-2) → 2,3,4,9-tetrahydro-1-(4-methoxyphenyl)-2-tosyl-1H-pyrido[3,4-b]indole (296797-76-7)

Guidance literature:

With pyridine; potassium carbonate; In dichloromethane; at 20 ℃; Cooling with ice;

DOI:10.1002/ejoc.201001153

Reference yield:

tryptamine (61-54-1) → 2,3,4,9-tetrahydro-1-(4-methoxyphenyl)-2-tosyl-1H-pyrido[3,4-b]indole (296797-76-7)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 8 h / Reflux

2: triethylamine / dichloromethane

With acetic acid; triethylamine; In dichloromethane;

DOI:10.1002/chem.201705202

upstream raw materials:

carbon monoxide

phenylhydrazine

p-toluenesulfonyl chloride

1-(4-methoxyphenyl)-1,2,3,4-tetrahydro-1H-pyrido[3,4-b]indole

Downstream raw materials:

1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indole

1-(4-methoxyphenyl)-4, 9-dihydro-3H-pyrido[3,4-b]indole