cis-2,3-Diphenylpiperazine

Base Information

• Chemical Name: cis-2,3-Diphenylpiperazine
• CAS No.: 81601-99-2
• Molecular Formula: C₁₆H₁₈N₂
• Molecular Weight: 238.332
• DSSTox Substance ID: DTXSID60512917
• Wikidata: Q82372359

Synonyms:CIS-2,3-DIPHENYLPIPERAZINE;81601-99-2;(2R,3S)-2,3-Diphenylpiperazine;DTXSID60512917;VT1001

Chemical Property of cis-2,3-Diphenylpiperazine

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 238.146998583
• Heavy Atom Count: 18
• Complexity: 216

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CNC(C(N1)C2=CC=CC=C2)C3=CC=CC=C3
• Isomeric SMILES: C1CN[C@@H]([C@@H](N1)C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of cis-2,3-Diphenylpiperazine

There total 22 articles about cis-2,3-Diphenylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1E,1’E)-N,N’-(ethane-1,2-diyl)bis(1-phenylmethanimine) (104-71-2) → (±)-2,3-diphenylpiperazine (70708-34-8,81601-99-2,81602-00-8,133695-17-7,143699-24-5)

Guidance literature:

With niobium pentachloride; zinc; In methanol; at 20 ℃; for 1h;

DOI:10.1002/ejoc.200500301

Reference yield: 95.0%

N,N'-Bis-[1-phenyl-meth-(Z)-ylidene]-ethane-1,2-diamine → (±)-2,3-diphenylpiperazine (70708-34-8,81601-99-2,81602-00-8,133695-17-7,143699-24-5)

Guidance literature:

With methanesulfonic acid; zinc; In tetrahydrofuran; at -50 ℃; for 12h;

DOI:10.1021/jo00118a013

Reference yield: 51.0%

(R,S)-5,6-diphenylpiperazine-2,3-dione (1609286-01-2,56477-89-5) → (R,S)-2,3-diphenylpiperazine (81601-99-2)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 ℃; Reflux;

upstream raw materials:

2,3-diphenyl-5,6-dihydropyrazine

2,3-diphenylpyrazine

i-Amyl alcohol

benzil

Downstream raw materials:

(R,R)-tert-butyl-4-benzyl-2,3-diphenyl-1-piperazinecarboxylate

(R,R)-1-benzyl-2,3-diphenylpiperazine

(3R,4R)-8-octyl-3,4,6-triphenyl-3,4-dihydropyrrolo[1,2-a]pyrazine

C₃₈H₃₄N₂

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