104-71-2

Usage

Chemical Properties

light yellow to yellow crystalline powder

Upstream product

• 100-52-7 benzaldehyde 
• 107-15-3 ethylenediamine 
• 4222-25-7 3-bromo-3-phenyl-3H-diazirine 
• 100-51-6 benzyl alcohol 
• 100-46-9 benzylamine 
• 24692-44-2 3,4-dihydro-1,2,5-thiadiazole 

Downstream Products

• 857787-79-2 N-(1-phenyl-propyl)-ethylenediamine 
• 83027-13-8 N,N'-bis(diphenylmethyl)-1,2-ethanediamine 
• 56655-17-5 Met-1 
• 140-28-3 N,N'-Dibenzylethylenediamine 
• 4152-09-4 N-benzylethylenediamine 
• 34235-59-1 N,N'-bis-(α-diethoxyphosphoryl-benzyl)-ethylenediamine 
• 32116-96-4 2,6,2',6'-tetraphenyl-2,3,2',3'-tetrahydro-3,3'-ethane-1,2-diyl-bis-[1,4,3]oxathiazine 4,4,4',4'-tetraoxide 
• 37975-93-2 2,6,2',6'-tetraphenyl-2,3,2',3'-tetrahydro-3,3'-ethane-1,2-diyl-bis-[1,3,5]thiadiazin-4-one 
• 37975-92-1 2,6,2',6'-tetraphenyl-2,3,2',3'-tetrahydro-3,3'-ethane-1,2-diyl-bis-[1,3,5]oxadiazin-4-one 
• 17799-72-3 2,2'-diphenyl-2,3,2',3'-tetrahydro-3,3'-ethane-1,2-diyl-bis-benzo[e][1,3]oxazin-4-one 
• 112629-63-7 1-benzyl-3-benzoyl-2-phenylimidazolidine 
• 87645-26-9 1,3-dibenzoyl-2-phenylimidazolidine 
• 75189-90-1 C₁₈H₂₂N₂⁽²⁺⁾*2CH₃O₄S^(1-) 
• 94908-32-4 N-<1-Phenyl-2,2,2-trichlor-aethyl>-benzyliden-aethylendiamin 

Relevant academic research and scientific papers

Synthesis of α-(alkoxysilyl)acetic esters. A route to 1,2 diols

An easy route to α-(alkoxysilyl)acetic esters and their utilization is described. It involves a two-step sequence carried out in one pot Rhodium catalyzed Si-H insertion of a carbenoid, generated by decomposition of N2CHCO2Et, followed by a nucleophilic attack onto the Si-Cl bond by an alcohol. Alkylation of the title esters, reduction of the ester function and finally oxidation of the C-Si bond provide a facile entry to 1,2 diols.

Stereoselective synthesis of cis-bis-β-lactams linked with an ethylene bridge

An efficient synthesis of (±)-cis-bis-β-lactams (5 and 6) via cycloaddition reaction of bisimines (3a-c) with acid chlorides (4) in the presence of triethylamine in very good yield is described. (C) 2000 Published by Elsevier Science Ltd.

A new macrocyclic heterobinuclear Cu(II)-Zn(II) complex: synthesis, crystal structure, phosphate hydrolysis, and DNA binding studies

A new macrocyclic heterobinuclear Cu(II)-Zn(II) complex was synthesized and characterized by elemental analysis, FT-IR, ES-MS, and single-crystal X-ray diffraction. Five-coordinate geometry for the new complex is proposed. The copper…zinc distance bridged by two phenolic oxygens and a acetate ligand is 2.9508 ?. The phosphate ester hydrolysis activity and the DNA binding ability of the complex were studied. The results showed that the present complex has an efficient catalytic activity of phosphoester bond cleavage. The catalytic rate constant kcat for the hydrolysis of 4-nitrophenyl phosphate disodium salt hexahydrate (pNPP) by the synthesized complex is 2.69 × 10?4 s?1 and 105 times faster than the spontaneous hydrolysis of the phosphate monoester. The complex shows a good binding ability to calf thymus (CT-DNA) and the corresponding binding constant is 1.9 × 105 M?1. The linear Stern-Volmer quenching constant obtained by the fluorescent spectroscopic is 6.3 × 104 M?1.

An efficient electrochemical method for the synthesis of quinoxaline-dione derivatives from oxidation of catechols in the presence of N1, N 2-dibenzylethane-1,2-diamine

A series of 1,4-dibenzyl-1,2,3,4-tetrahydroquinoxaline-6,7-dione derivatives (6a-6c) were electrosynthesized. In the present work, electrochemical oxidation of catechols 1a-1d in the presence of the N 1,N2-dibenzylethane-1,2-diamine (3) as a nucleophile, has been studied in aqueous solutions using cyclic voltammetry and controlled-potential coulometry (CPC) methods. Various parameters such as the applied potential, pH of the electrolytic solution, cell configuration and also purification techniques, were carried out to optimize the yields of corresponding products. New quinoxaline-6,7-dione derivatives were synthesized in excellent yield using an electrochemical procedure coupled with a Schiff base as a facile, efficient and practical method.

Synthesis and supramolecular features of hybrid POM/onium solid-state assemblies

Polyoxomolybdate-based organic-inorganic hybrid architectures were synthesised and characterised by X-ray crystallography. The supramolecular assemblies present rows of metallic clusters H-bonded by ammonium cations, with a 1:2 molybdate/ammonium ratio. The organic moieties of the ammonium cations establish hydrophobic contact among them such as van der Waals, C-Hπ and ππ interactions that stabilise the supramolecular architectures. In particular, for compound 5 the n-alkyl tails pack closely together giving a lipid-like bilayer. In compound 6, the aromatic phenyl rings of the organic cation allow the stabilisation of the supramolecular architecture by C-Hπ and ππ interactions. Regarding the X-ray structure of the compound 11, the tetraanionic octa-molybdate [Mo8O26]4- cluster is surrounded by four ethyl-triphenyl-phosphonium cations. Running along the b-axis open channels are occupied by DMF solvent molecules. Interestingly, a soaking experiment in n-pentane with the corresponding crystals of compound 11 afforded to a crystal structure very different from the native one. Van der Waals, C-Hπ and ππ interactions between large organic moieties are fundamental in the stabilization of hybrid organic-inorganic POM architectures.

Synthesis and antitubercular activity of ferrocenyl diaminoalcohols and diamines

A total of 21 ferrocenyl and benzyl diaminoalcohols and diamines were synthesized and evaluated against Mycobacterium tuberculosis H37Rv. Interestingly, ferrocenyl diamines exhibit better activities than ferrocenyl diaminoalcohols.

Synthesis of single-component urethane sealants

Single-component urethane sealing formulations with aldimines as cross-linking agents were developed. The temperature dependence of the curing time of the sealants was examined. The influence of the -CH=N-/-NCO ratio and of fillers (industrial carbon and chalk) on their physicochemical properties was studied.

Synthesis and spectral data of new 1,2-bis-(2-hetaryl-4-oxothiazolidin-3- yl)ethanes and 1,4-bis-(2-hetaryl-4-oxothiazolidin-3-yl)butanes

New α,ω-bis-(2-hetaryl-4-oxothiazolidin-3-yl)alkanes were prepared via a common two step procedure using N,N-bis-hetarylidenamines condensation with α-mercaptoacetic acid. The used bis-aldimines were obtained from reaction between ethylenediamine or putrescine and benzaldehyde or the isomeric pyridinecarboxyaldehydes. The bis-(2-phenyl-4-oxothiazolidin-3-yl) alkanes were prepared by one-pot three component reaction of diamine, aldehyde and α-mercaptoacetic acid under very mild conditions.

Design, synthesis and biological evaluation of Schiff’s base derivatives as multifunctional agents for the treatment of Alzheimer’s disease

A series of Schiff’s base derivatives was rationally designed, synthesized, and evaluated as multi-function agents for the treatment of Alzheimer’s disease (AD). The results revealed that compound 3b was a novel multifunctional agent. It acted as a highly selective monoamine oxidase-B inhibitor (IC50 = 8.4 nM), which was explained by the docking study. Compound 3b also was an antioxidant agent (2.3 eq) and could significantly inhibit self-induced Aβ1-42 aggregation (31.8%). Meanwhile, compound 3b was a selective metal chelator and could inhibit Cu2+-induced Aβ1-42 aggregation (62.3%). Furthermore, compound 3b presented good neuroprotective effects on H2O2-induced PC12 cell injury. More importantly, compound demonstrated good blood brain barrier permeability and druglike properties. Therefore, compound 3b, a promising multi-targeted active molecule, offers an attractive starting point for further study in the drug-discovery process against AD.[Figure not available: see fulltext.].

Synthesis and study of N, N' -(ethane-1,2-diyl)bis(1-phenyl methanimine) and their complex derivative with in-vivo and in-vitro Bacterial biological study

In this research, the synthesis and biological activity evaluation of N, N'-(ethane-1,2-diyl)bis(1-phenyl methanimine) as Schiff base with Zinc (II) dithiocarbamate complex are successfully reported. The suggested geometry around zinc ion centre was determined using selected unique physicochemical and spectroscopic techniques. These include melting point, conductance, FTIR, UV-Vis, mass spectroscopy and 1H-NMR spectroscopy. The analytical as well as the spectroscopic characterization data proves the formation of zinc complex with general formula [Zn(L)]2 and the complex of this ion is adopting tetrahedral geometry about the metal centre. Furthermore, the present study was carried out to evaluate antibacterial activity of obtained Schiff base ligand and Zn complex against five strains of bacteria (Staphylococcus aureus, Escherichia coli, Lacto bacillus, Klebsiella Pneumonae,and Salmonella typhi). The results of antimicrobial screening suggest that Schiff bases can show a considerable activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia and Salmonella typhi while Zn-complex was reported to be more active against all bacterial strains which is used in this test. The antibacterial activity of each compound has been examined practically (in vivo) by treating burns rats infected with tested bacteria (Staphylococcus aureus and Salmonella typhi), the results have shown signs of good recovery at short time if it compared with antibiotic Ofloxacin (OFX) used at the same time. And the number of bacteria was reduced significantly (P 0.001) during the treatment days. Furthermore, the results showed that Zn-complex is effective in treating various skin conditions; it is preferable to use it in the treatment of pathological injuries and against other skin infections.