1-(Piperazin-1-yl)propan-2-ol

Base Information

• Chemical Name: 1-(Piperazin-1-yl)propan-2-ol
• CAS No.: 1074-54-0
• Molecular Formula: C7H16 N2 O
• Molecular Weight: 144.217
• Hs Code.: 2933599090
• European Community (EC) Number: 214-042-4
• NSC Number: 86963
• DSSTox Substance ID: DTXSID801308940
• Nikkaji Number: J217.191K
• Mol file: 1074-54-0.mol

Synonyms:1-(piperazin-1-yl)propan-2-ol;1074-54-0;1-piperazin-1-yl-propan-2-ol;1-piperazin-1-ylpropan-2-ol;1-(1-piperazinyl)-2-propanol;alpha-Methylpiperazine-1-ethanol;alpha-Methyl-1-piperazineethanol;NSC86963;2-hydroxypropyl piperazine;NCIOpen2_001117;SCHEMBL154268;1-(2-hydroxypropyl)piperazine;DTXSID801308940;MFCD00130195;NSC-86963;AKOS005062878;AT30916;SB30486;1-(1-Piperazinyl)-2-propanol, AldrichCPR;CS-0342939;EN300-68555;A801755;Z600448684

Chemical Property of 1-(Piperazin-1-yl)propan-2-ol

Chemical Property:

• Vapor Pressure: 0.00295mmHg at 25°C
• Boiling Point: 252.3 °C at 760 mmHg
• Flash Point: 106.4 °C
• PSA: 35.50000
• Density: 1.007 g/cm³
• LogP: -0.46090
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 144.126263138
• Heavy Atom Count: 10
• Complexity: 91.6

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(Piperazin-1-yl)propan-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CN1CCNCC1)O

Technology Process of 1-(Piperazin-1-yl)propan-2-ol

There total 8 articles about 1-(Piperazin-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

piperazine (110-85-0) + methyloxirane (75-56-9,16033-71-9) → 1-(1-piperazinyl)-2-propanol (1074-54-0)

Guidance literature:

In various solvent(s); at 40 ℃; for 0.5h;

Reference yield: 46.0%

N,N'-bis-allylpiperazine (13173-24-5) → 3-(1-piperazinyl)-1-propanol (5317-32-8) + 1-(1-piperazinyl)-2-propanol (1074-54-0) + 3,3'-(piperazine-1,4-diyl)bis(propan-1-ol) (28765-60-8) + 3-(4-propyl-1-piperazinyl)-1-propanol (100500-96-7)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; triethylamine borane; Yield given. Multistep reaction. Further byproducts given; 1. heating to 120 deg C; 2. aq. THF, heating, 3 h;

Reference yield: 34.0%

2-hydroxy-1-(piperazin-1-yl)propan-1-one (100500-89-8) → 1-(1-piperazinyl)-2-propanol (1074-54-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 3h; Heating;

upstream raw materials:

piperazine

methyloxirane

N,N'-bis-allylpiperazine

2-hydroxy-1-(piperazin-1-yl)propan-1-one

Downstream raw materials:

piperazine

2-methyl-1,4-diazabicyclo [2,2,2]octane

8-Benzylthio-2-[N-(2-hydroxy-propyl)-piperazino]-4-morpholino-pyrimido-[5,4-d]-pyrimidine

1-{4-[(4-Isopropyl-phenyl)-(4-methyl-isothiazol-5-yl)-methyl]-piperazin-1-yl}-propan-2-ol

Refernces

• 1、 Kafka, Stanislav,Ferles, Miloslav. "HYDROBORATION OF 1,4-DIALLYLPIPERAZINE". . p. 2275 - 2283. Retrieved 2007/10/02.
• 2、 Petrova, L. S.,Davidenkov, L. R.,Medved', S. S.. "PREPARATION OF MONO-N-SUBSTITUTED PIPERAZINES". . p. 174 - 178. Retrieved 2007/10/02.