1,4-Piperazinedipropanol

Base Information

• Chemical Name: 1,4-Piperazinedipropanol
• CAS No.: 28765-60-8
• Molecular Formula: C10H22 N2 O2
• Molecular Weight: 202.297
• NSC Number: 93265
• DSSTox Substance ID: DTXSID50293980
• Wikidata: Q82033011
• Mol file: 28765-60-8.mol

Synonyms:1,4-Piperazinedipropanol;28765-60-8;NSC93265;3-[4-(3-hydroxypropyl)piperazin-1-yl]propan-1-ol;NCIOpen2_006004;SCHEMBL972563;DTXSID50293980;NSC-93265;n,n'-di-(3-hydroxypropyl) piperazine;3,3'-(piperazine-1,4-diyl)dipropan-1-ol

Chemical Property of 1,4-Piperazinedipropanol

Chemical Property:

• Boiling Point: 344.9°Cat760mmHg
• Flash Point: 171.3°C
• Density: 1.054g/cm³
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 202.168127949
• Heavy Atom Count: 14
• Complexity: 120

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1CCCO)CCCO

Technology Process of 1,4-Piperazinedipropanol

There total 4 articles about 1,4-Piperazinedipropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.9%

piperazine (110-85-0) + 1-chloro-3-hydroxypropane (627-30-5) → 3-(1-piperazinyl)-1-propanol (5317-32-8) + 3,3'-(piperazine-1,4-diyl)bis(propan-1-ol) (28765-60-8)

Guidance literature:

With hydrogenchloride; In methanol; water; for 8.5h; Inert atmosphere;

Reference yield: 46.0%

N,N'-bis-allylpiperazine (13173-24-5) → 3-(1-piperazinyl)-1-propanol (5317-32-8) + 1-(1-piperazinyl)-2-propanol (1074-54-0) + 3,3'-(piperazine-1,4-diyl)bis(propan-1-ol) (28765-60-8) + 3-(4-propyl-1-piperazinyl)-1-propanol (100500-96-7)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; triethylamine borane; Yield given. Multistep reaction. Further byproducts given; 1. heating to 120 deg C; 2. aq. THF, heating, 3 h;

Reference yield: 46.0%

N,N'-bis-allylpiperazine (13173-24-5) → 3-(1-piperazinyl)-1-propanol (5317-32-8) + 3,3'-(piperazine-1,4-diyl)bis(propan-1-ol) (28765-60-8) + 1-(4-propyl-1-piperazinyl)-2-propanol (100500-94-5) + 3-(4-propyl-1-piperazinyl)-1-propanol (100500-96-7)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; triethylamine borane; Yield given. Multistep reaction. Further byproducts given; 1. heating to 120 deg C; 2. aq. THF, heating, 3 h;

upstream raw materials:

piperazine

1-chloro-3-hydroxypropane

N,N'-bis-allylpiperazine

Downstream raw materials:

(2,4,5-Trichloro-phenoxy)-acetic acid 3-(4-{3-[2-(2,4,5-trichloro-phenoxy)-acetoxy]-propyl}-piperazin-1-yl)-propyl ester; hydrochloride

(2,4,6-Trimethyl-phenoxy)-acetic acid 3-(4-{3-[2-(2,4,6-trimethyl-phenoxy)-acetoxy]-propyl}-piperazin-1-yl)-propyl ester; hydrochloride

Refernces

• 1、 Kafka, Stanislav,Ferles, Miloslav. "HYDROBORATION OF 1,4-DIALLYLPIPERAZINE". . p. 2275 - 2283. Retrieved 2007/10/02.