(1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)-N,N-dimethylcyclopentanecarboxamide

Base Information

Chemical Name:(1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)-N,N-dimethylcyclopentanecarboxamide
CAS No.:1263371-70-5
Molecular Formula:C₂₅H₂₇ClFN₅O
Molecular Weight:467.974
Hs Code.:

Synonyms:(1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)-N,N-dimethylcyclopentanecarboxamide

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Chemical Property of (1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)-N,N-dimethylcyclopentanecarboxamide

Chemical Property:

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Technology Process of (1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)-N,N-dimethylcyclopentanecarboxamide

There total 7 articles about (1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)-N,N-dimethylcyclopentanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1263371-66-9
(1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)cyclopentanecarboxylic acid

: 124-40-3
dimethyl amine

: 1263371-70-5
(1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)-N,N-dimethylcyclopentanecarboxamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1263374-08-8
5'-chloro-2'-fluoro-N-(3-fluorobenzyl)-[2,4'-dipyridine]-6-amine

: 71830-07-4
(1S,3R)-3-aminocyclopentanecarboxylic acid

: 1263371-70-5
(1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)-N,N-dimethylcyclopentanecarboxamide

Guidance literature:: With potassium hydroxide; In 1,4-dioxane; at 100 ℃; for 18h;

Reference yield:

: 100-82-3
(3-fluorophenyl)methanamine

: 1263371-70-5
(1S,3R)-3-(5'-chloro-6-(3-fluorobenzylamino)-2,4'-bipyridin-2'-yl-amino)-N,N-dimethylcyclopentanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 168 h / 115 - 120 °C / Inert atmosphere

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 3 h / 100 °C

3: potassium hydroxide / 1,4-dioxane / 18 h / 100 °C / Sealed vial

4: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 18 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; N,N-dimethyl-formamide; 2: Suzuki Coupling;