2-[4-(3-Diethylamino-propylcarbamoyl)-5-trifluoromethyl-pyrazol-1-yl]-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid methyl ester

Base Information

Chemical Name:2-[4-(3-Diethylamino-propylcarbamoyl)-5-trifluoromethyl-pyrazol-1-yl]-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid methyl ester
CAS No.:1027313-56-9
Molecular Formula:C₂₄H₂₅F₆N₅O₃S
Molecular Weight:577.551
Hs Code.:

2-[4-(3-Diethylamino-propylcarbamoyl)-5-trifluoromethyl-pyrazol-1-yl]-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid methyl ester

Synonyms:2-[4-(3-Diethylamino-propylcarbamoyl)-5-trifluoromethyl-pyrazol-1-yl]-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid methyl ester

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Chemical Property of 2-[4-(3-Diethylamino-propylcarbamoyl)-5-trifluoromethyl-pyrazol-1-yl]-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid methyl ester

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Technology Process of 2-[4-(3-Diethylamino-propylcarbamoyl)-5-trifluoromethyl-pyrazol-1-yl]-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid methyl ester

There total 7 articles about 2-[4-(3-Diethylamino-propylcarbamoyl)-5-trifluoromethyl-pyrazol-1-yl]-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 159886-03-0
5-Bromo-2-[4-[3-(N,N-diethylamino)propylcarbamoyl]-5-(trifluoromethyl)pyrazol-1-yl]-4-(3-trifluoromethylphenyl)-thiazole

: 1027313-56-9
2-[4-(3-Diethylamino-propylcarbamoyl)-5-trifluoromethyl-pyrazol-1-yl]-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid methyl ester

Guidance literature:: With bis(triphenylphosphine)palladium(II)-chloride; triethylamine; at 100 ℃; for 48h; under 6722.9 Torr;
DOI:10.1021/jm00001a008

Reference yield:

: 1048670-08-1
2-[1-ethoxy-meth-(Z)-ylidene]-4,4,4-trifluoro-3-oxo-butyric acid ethyl ester

: 1027313-56-9
2-[4-(3-Diethylamino-propylcarbamoyl)-5-trifluoromethyl-pyrazol-1-yl]-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) EtOH, RT, 1 h, 2.) EtOH, refux, 3 h

2: 98 percent / N-bromosuccinimide, AIBN / CHCl₃ / 8 h / Heating

3: 88 percent / KOH / ethanol / 3 h / Heating

4: 1.) carbonyldiimidazole (CDI) / 1.) DMF, RT, 30 min, 2.) DMF, 2 h

5: 52 percent / Et₃N, bis(triphenylphosphine)palladium(II) chloride / 48 h / 100 °C / 6722.9 Torr

With potassium hydroxide; N-Bromosuccinimide; bis(triphenylphosphine)palladium(II)-chloride; 2,2'-azobis(isobutyronitrile); triethylamine; 1,1'-carbonyldiimidazole; In ethanol; chloroform;
DOI:10.1021/jm00001a008

Reference yield:

: 349-76-8
3'-(trifluoromethyl)acetophenone

: 1027313-56-9
2-[4-(3-Diethylamino-propylcarbamoyl)-5-trifluoromethyl-pyrazol-1-yl]-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / Br₂ / diethyl ether / 3 h / Ambient temperature

2: 1.) EtOH, RT, 1 h, 2.) EtOH, refux, 3 h

3: 98 percent / N-bromosuccinimide, AIBN / CHCl₃ / 8 h / Heating

4: 88 percent / KOH / ethanol / 3 h / Heating

5: 1.) carbonyldiimidazole (CDI) / 1.) DMF, RT, 30 min, 2.) DMF, 2 h

6: 52 percent / Et₃N, bis(triphenylphosphine)palladium(II) chloride / 48 h / 100 °C / 6722.9 Torr

With potassium hydroxide; N-Bromosuccinimide; bis(triphenylphosphine)palladium(II)-chloride; 2,2'-azobis(isobutyronitrile); bromine; triethylamine; 1,1'-carbonyldiimidazole; In diethyl ether; ethanol; chloroform;
DOI:10.1021/jm00001a008