1-Methyl-1-phenylhydrazine

Base Information

• Chemical Name: 1-Methyl-1-phenylhydrazine
• CAS No.: 618-40-6
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 29280090
• European Community (EC) Number: 210-547-9
• NSC Number: 525518
• UNII: YHB9CZB63U
• DSSTox Substance ID: DTXSID2060678
• Nikkaji Number: J29.560D
• Wikidata: Q27294527
• Mol file: 618-40-6.mol

Synonyms:N-methyl-N-phenyl-hydrazine

Chemical Property of 1-Methyl-1-phenylhydrazine

Chemical Property:

• Appearance/Colour: clear yellow to orange-brown liquid
• Vapor Pressure: 0.0324mmHg at 25°C
• Melting Point: 1.066 g/cm³
• Refractive Index: n20/D 1.583(lit.)
• Boiling Point: 243.3 °C at 760 mmHg
• PKA: 5.37±0.10(Predicted)
• Flash Point: 93.6 °C
• PSA: 29.26000
• Density: 1.038
• LogP: 1.69680
• Storage Temp.: 0-6°C
• Water Solubility.: Slightly soluble
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 77

Purity/Quality:

97% ^*data from raw suppliers

1-Methyl-1-phenylhydrazine >95.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN(C1=CC=CC=C1)N
• Uses: 1-Methyl-1-phenylhydrazine is used to make other chemicals.

Technology Process of 1-Methyl-1-phenylhydrazine

There total 50 articles about 1-Methyl-1-phenylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-methyl-N-nitrosoaniline (614-00-6) → 1-Methyl-1-phenylhydrazine (618-40-6)

Guidance literature:

With Ti(II)reagent(A); In diethyl ether; for 0.5h; Ambient temperature;

DOI:10.1016/0040-4020(82)80184-1

Reference yield: 89.0%

3-amino-4,5-dihydro-1,4-dimethyl-1-phenyl-1H-pyrazolium iodide (84533-99-3) → 1-Methyl-1-phenylhydrazine (618-40-6)

Guidance literature:

With sodium hydroxide; for 6.5h; Heating;

Reference yield: 89.0%

3-amino-4,5-dihydro-1,4-dimethyl-1-phenyl-1H-pyrazolium iodide (84533-99-3) → 3-hydroxypropanoic acid sodium salt (6487-38-3) + 1-Methyl-1-phenylhydrazine (618-40-6)

Guidance literature:

With sodium hydroxide; for 6.5h; Mechanism; Heating; var. 1,1-disubstituted-3-amino-4,5-dihydro-1H-pyrazolium halides;

upstream raw materials:

N-methyl-N-nitrosoaniline

acetic acid

sodium acetate

N-methyl-N-nitroaniline

Downstream raw materials:

N-methyl-N-phenyl-formamidrazone

2-pyridinecarboxaldehyde N-methyl-N-phenylhydrazone

2-(N-methyl-N-phenylamino)-1H-isoindole-1,3(2H)-dione

piperonal-(methyl-phenyl-hydrazone)

Refernces

Fischer indole synthesis in water: Simple, efficient preparation of naltrindole, naltriben and analogs

10.1039/b920864j

The research presents an environmentally friendly method for synthesizing naltrindole (NTI), naltriben (NTB), and their analogs using Fischer indole synthesis under mildly acidic, purely aqueous conditions. The study explores the preparation of these compounds, which are valuable tools for opioid receptor pharmacology studies, using hydrochloride salts of naltrexone and various phenylhydrazines in boiling water, achieving good to excellent yields and high purities without the need for organic solvents or harsh acids. The chemicals that played a crucial role in this research include naltrexone hydrochloride (NTX·HCl), phenylhydrazine hydrochloride, and other substituted phenylhydrazines such as 1-methyl-1-phenylhydrazine, o-chlorophenylhydrazine, o-fluorophenylhydrazine, and o-nitrophenylhydrazine. The study also utilized dilute hydrochloric acid (HCl) to facilitate the synthesis, and in some cases, sulfuric acid (H?SO?) for comparison. The products were obtained through simple filtration or centrifugation, highlighting the simplicity and efficiency of the aqueous Fischer synthesis method.