2-[(4R,5R)-2,2-Dimethyl-5-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-[1,3]dioxolan-4-yl]-3,5-dimethoxy-benzaldehyde

Base Information

Chemical Name:2-[(4R,5R)-2,2-Dimethyl-5-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-[1,3]dioxolan-4-yl]-3,5-dimethoxy-benzaldehyde
CAS No.:173074-12-9
Molecular Formula:C₂₅H₃₄O₅S₂
Molecular Weight:478.674
Hs Code.:

Synonyms:2-[(4R,5R)-2,2-Dimethyl-5-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-[1,3]dioxolan-4-yl]-3,5-dimethoxy-benzaldehyde

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Chemical Property of 2-[(4R,5R)-2,2-Dimethyl-5-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-[1,3]dioxolan-4-yl]-3,5-dimethoxy-benzaldehyde

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Technology Process of 2-[(4R,5R)-2,2-Dimethyl-5-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-[1,3]dioxolan-4-yl]-3,5-dimethoxy-benzaldehyde

There total 5 articles about 2-[(4R,5R)-2,2-Dimethyl-5-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-[1,3]dioxolan-4-yl]-3,5-dimethoxy-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026158-13-3
{2-[(4R,5R)-2,2-Dimethyl-5-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-[1,3]dioxolan-4-yl]-3,5-dimethoxy-phenyl}-methanol

: 173074-12-9
2-[(4R,5R)-2,2-Dimethyl-5-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-[1,3]dioxolan-4-yl]-3,5-dimethoxy-benzaldehyde

Guidance literature:: With manganese(IV) oxide; In benzene; for 19h; Yield given; Ambient temperature;
DOI:10.1021/jo9519367

Reference yield:

: 150966-58-8
5,5-(ethylenedioxy)-2,,6,6-trimethyl-1-iodocyclohexene

: 173074-12-9
2-[(4R,5R)-2,2-Dimethyl-5-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-[1,3]dioxolan-4-yl]-3,5-dimethoxy-benzaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: BF₃*OEt₂ / CH₂Cl₂ / 3 h / Ambient temperature

2: 1.) t-BuLi / 1) THF, pentane, -78 deg C, 30 min; 2) THF, pentane, -78 deg C, 30 min

3: 96 percent / PPTS / CH₂Cl₂ / 3.5 h / 0 °C

4: tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature

5: MnO₂ / benzene / 19 h / Ambient temperature

With manganese(IV) oxide; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; tert.-butyl lithium; pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/jo9519367

Reference yield:

: 173073-81-9
7-Iodo-6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-ene

: 173074-12-9
2-[(4R,5R)-2,2-Dimethyl-5-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-[1,3]dioxolan-4-yl]-3,5-dimethoxy-benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) t-BuLi / 1) THF, pentane, -78 deg C, 30 min; 2) THF, pentane, -78 deg C, 30 min

2: 96 percent / PPTS / CH₂Cl₂ / 3.5 h / 0 °C

3: tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature

4: MnO₂ / benzene / 19 h / Ambient temperature

With manganese(IV) oxide; tetrabutyl ammonium fluoride; tert.-butyl lithium; pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/jo9519367