(1R,2R)-1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6-dimethoxy-phenyl]-2-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-ethane-1,2-diol

Base Information

Chemical Name:(1R,2R)-1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6-dimethoxy-phenyl]-2-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-ethane-1,2-diol
CAS No.:173073-86-4
Molecular Formula:C₂₈H₄₆O₅S₂Si
Molecular Weight:554.888
Hs Code.:

Synonyms:(1R,2R)-1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6-dimethoxy-phenyl]-2-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-ethane-1,2-diol

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Chemical Property of (1R,2R)-1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6-dimethoxy-phenyl]-2-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-ethane-1,2-diol

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Technology Process of (1R,2R)-1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6-dimethoxy-phenyl]-2-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-ethane-1,2-diol

There total 1 articles about (1R,2R)-1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6-dimethoxy-phenyl]-2-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-ethane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 150966-58-8
5,5-(ethylenedioxy)-2,,6,6-trimethyl-1-iodocyclohexene

: 173073-86-4
(1R,2R)-1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6-dimethoxy-phenyl]-2-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-ethane-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1: BF₃*OEt₂ / CH₂Cl₂ / 3 h / Ambient temperature

2: 1.) t-BuLi / 1) THF, pentane, -78 deg C, 30 min; 2) THF, pentane, -78 deg C, 30 min

With boron trifluoride diethyl etherate; tert.-butyl lithium; In dichloromethane;
DOI:10.1021/jo9519367

Reference yield: 96.0%

: 115-19-5
2-methyl-but-3-yn-2-ol

: 173073-86-4
(1R,2R)-1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6-dimethoxy-phenyl]-2-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-ethane-1,2-diol

: 173074-11-8
tert-Butyl-{2-[(4R,5R)-2,2-dimethyl-5-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-[1,3]dioxolan-4-yl]-3,5-dimethoxy-benzyloxy}-dimethyl-silane

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; at 0 ℃; for 3.5h;
DOI:10.1021/jo9519367

Reference yield:

: 173073-86-4
(1R,2R)-1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6-dimethoxy-phenyl]-2-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-ethane-1,2-diol

: 173073-87-5
2-[(4R,5R)-2,2-Dimethyl-5-(2,6,6-trimethyl-5-oxo-cyclohex-1-enyl)-[1,3]dioxolan-4-yl]-3,5-dimethoxy-benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / PPTS / CH₂Cl₂ / 3.5 h / 0 °C

2: tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature

3: MnO₂ / benzene / 19 h / Ambient temperature

4: 71 percent / CaCO₃, HgCl₂ / acetonitrile; H₂O / 13 h / Ambient temperature

With manganese(IV) oxide; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; calcium carbonate; mercury dichloride; In tetrahydrofuran; dichloromethane; water; acetonitrile; benzene;
DOI:10.1021/jo9519367