5-chloro-4-(1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxylic acid

Base Information

Chemical Name:5-chloro-4-(1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxylic acid
CAS No.:1047630-55-6
Molecular Formula:C₉H₇ClN₂O₂S
Molecular Weight:242.686
Hs Code.:
Mol file:1047630-55-6.mol

Synonyms:5-chloro-4-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxylic acid

Suppliers and Price of 5-chloro-4-(1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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AK Scientific
5-chloro-4-(1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxylicacid
1g
$ 485.60

Total 4 raw suppliers

Chemical Property of 5-chloro-4-(1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxylic acid

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

5-chloro-4-(1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 5-chloro-4-(1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxylic acid

There total 5 articles about 5-chloro-4-(1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1047630-52-3
methyl 5-chloro-4-(1-methylpyrazol-5-yl)-2-thiophenecarboxylate

: 1047630-55-6
5-chloro-4-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxylic acid

Guidance literature:: methyl 5-chloro-4-(1-methylpyrazol-5-yl)-2-thiophenecarboxylate; With sodium hydroxide; In tetrahydrofuran; methanol; water; at 20 - 50 ℃; for 2 - 12h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=2;

Reference yield:

: 24065-33-6
5-Chlorothiophene-2-carboxylic acid

: 1047630-55-6
5-chloro-4-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 12 - 20 h / 50 - 55 °C

2.1: N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride / acetic acid / 48 h / 70 °C

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 15 h / 80 °C

4.1: sodium hydroxide / tetrahydrofuran; methanol; water / 2 - 12 h / 20 - 50 °C

4.2: pH 2

With sodium hydroxide; sulfuric acid; potassium carbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetic acid;

Reference yield:

: 35475-03-7
methyl 5-chloro-2-thiophenecarboxylate

: 1047630-55-6
5-chloro-4-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride; bromine / chloroform / 6 h / 25 °C

2.1: potassium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 1.5 h / 75 °C

3.1: sodium hydroxide / tetrahydrofuran; methanol; water / 2 - 12 h / 20 - 50 °C

3.2: pH 2

With aluminum (III) chloride; sodium hydroxide; bromine; potassium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; water;