1047630-52-3 Usage
General Description
2-Thiophenecarboxylic acid, 5-chloro-4-(1-methyl-1H-pyrazol-5-yl)-, methyl ester is a chemical compound that consists of a thiophene ring attached to a carboxylic acid group, as well as a chlorine atom and a methyl ester group. It is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and pharmaceutical compounds. 2-Thiophenecarboxylic acid, 5-chloro-4-(1-methyl-1H-pyrazol-5-yl)-, methyl ester possesses potential biological activity and has been studied for its anti-inflammatory and antifungal properties. Additionally, it has also been investigated for its potential use in the treatment of various diseases and conditions. However, it is important to handle this chemical with caution, as it may pose certain health and safety risks if not used properly.
Check Digit Verification of cas no
The CAS Registry Mumber 1047630-52-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,4,7,6,3 and 0 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1047630-52:
(9*1)+(8*0)+(7*4)+(6*7)+(5*6)+(4*3)+(3*0)+(2*5)+(1*2)=133
133 % 10 = 3
So 1047630-52-3 is a valid CAS Registry Number.
1047630-52-3Relevant articles and documents
AFURESERTIB: Protein kinase B (PKB) inhibitor Oncolytic
Conkel,Benson
, p. 541 - 546 (2014/12/11)
The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway plays key roles in cellular proliferation and survival. Mutations and alterations in this signal transduction pathway have been described in a variety of solid and hematopoietic malignancies, which may contribute to perpetuation of the disease in a number of ways. Increasing interest in targeting particular facets of this signaling cascade has led to the development of a number of novel anticancer agents, including afuresertib (GSK-2110183), an orally bioavailable pan-inhibitor of the RAC-alpha serine/threonine protein kinase, also referred to as protein kinase B or proto-oncogene c-Akt. The present review summarizes the preclinical and pharmacological aspects of afuresertib and early clinical experience.