(R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-morpholine-3-thione

Base Information

Chemical Name:(R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-morpholine-3-thione
CAS No.:1262859-24-4
Molecular Formula:C₁₁H₁₁BrN₂O₃S
Molecular Weight:331.19
Hs Code.:

Synonyms:(R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-morpholine-3-thione

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Chemical Property of (R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-morpholine-3-thione

Chemical Property:

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Technology Process of (R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-morpholine-3-thione

There total 10 articles about (R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-morpholine-3-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262859-23-3
(R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-morpholin-3-one

: 1262859-24-4
(R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-morpholine-3-thione

Guidance literature:: With Lawessons reagent; at 80 ℃; for 2h;

Reference yield:

: 127413-59-6
1-(3-bromo-5-nitrophenyl)ethanone

: 1262859-24-4
(R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-morpholine-3-thione

Guidance literature:: Multi-step reaction with 7 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 2.5 h / Reflux

1.2: Cooling with ice

2.1: cesium fluoride / tetrahydrofuran; hexane / 4 h / -50 - 0 °C

3.1: hydrogenchloride / toluene / 4 h / Reflux

4.1: diborane / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

5.1: potassium carbonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 0 °C / Inert atmosphere

6.1: potassium tert-butylate / tert-butyl alcohol / 0.5 h / 100 °C / Inert atmosphere

7.1: Lawessons reagent / 2 h / 80 °C

With Lawessons reagent; hydrogenchloride; potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; cesium fluoride; diborane; titanium(IV) tetraethanolate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 355134-13-3
3-bromo-5-nitrobenzaldehyde

: 1262859-24-4
(R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-morpholine-3-thione

Guidance literature:: Multi-step reaction with 9 steps

1.1: titanium tetrachloride / tetrahydrofuran; dichloromethane / 1 h / -78 - -30 °C

2.1: manganese(IV) oxide / 1,4-dioxane / 17 h / Reflux

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 2.5 h / Reflux

3.2: Cooling with ice

4.1: cesium fluoride / tetrahydrofuran; hexane / 4 h / -50 - 0 °C

5.1: hydrogenchloride / toluene / 4 h / Reflux

6.1: diborane / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

7.1: potassium carbonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 0 °C / Inert atmosphere

8.1: potassium tert-butylate / tert-butyl alcohol / 0.5 h / 100 °C / Inert atmosphere

9.1: Lawessons reagent / 2 h / 80 °C

With Lawessons reagent; hydrogenchloride; manganese(IV) oxide; potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; cesium fluoride; diborane; titanium(IV) tetraethanolate; titanium tetrachloride; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;