(R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Base Information

Chemical Name:(R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine
CAS No.:1262859-25-5
Molecular Formula:C₁₁H₁₂BrN₃O₃
Molecular Weight:314.139
Hs Code.:

Synonyms:(R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

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Technology Process of (R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

There total 12 articles about (R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262859-24-4
(R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-morpholine-3-thione

: 1262859-25-5
(R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: With tert.-butylhydroperoxide; ammonium hydroxide; ammonia; In methanol; water; at 20 ℃; for 2h;

Reference yield:

: 75-91-2
tert.-butylhydroperoxide

: 1262859-24-4
(R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-morpholine-3-thione

: 7803-49-8
hydroxylamine

: 1262859-25-5
(R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: With sodium thiosulfate; In methanol; ammonia;

Reference yield:

: 127413-59-6
1-(3-bromo-5-nitrophenyl)ethanone

: 1262859-25-5
(R)-5-(3-Bromo-5-nitro-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 2.5 h / Reflux

1.2: Cooling with ice

2.1: cesium fluoride / tetrahydrofuran; hexane / 4 h / -50 - 0 °C

3.1: hydrogenchloride / toluene / 4 h / Reflux

4.1: diborane / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

5.1: potassium carbonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 0 °C / Inert atmosphere

6.1: potassium tert-butylate / tert-butyl alcohol / 0.5 h / 100 °C / Inert atmosphere

7.1: Lawessons reagent / 2 h / 80 °C

8.1: tert.-butylhydroperoxide; ammonium hydroxide; ammonia / methanol / 2 h / 20 °C

With Lawessons reagent; hydrogenchloride; tert.-butylhydroperoxide; ammonium hydroxide; potassium tert-butylate; ammonia; potassium carbonate; N-ethyl-N,N-diisopropylamine; cesium fluoride; diborane; titanium(IV) tetraethanolate; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;