(S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl) ( 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrol-1-yl)methanone

Base Information

Chemical Name:(S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl) ( 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrol-1-yl)methanone
CAS No.:1430738-23-0
Molecular Formula:C₂₉H₅₂N₂O₄Si₂
Molecular Weight:548.914
Hs Code.:

Synonyms:(S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl) ( 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrol-1-yl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl) ( 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrol-1-yl)methanone

Chemical Property:

Purity/Quality:: ≥95% ^*data from raw suppliers

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Technology Process of (S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl) ( 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrol-1-yl)methanone

There total 17 articles about (S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl) ( 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrol-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1430738-22-9
(S)-(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrol-1-yl)(5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)phenyl)methanone

: 1430738-23-0
(S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl) ( 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrol-1-yl)methanone

Guidance literature:: With ammonium acetate; zinc; In ethanol; water; at 15 - 30 ℃;
DOI:10.1021/acs.joc.8b02876

Reference yield:

: 1430738-06-9
(S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-1-(5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)benzoyl)-4, 5-dihydro-1H-pyrrol-3-yl trifluoromethanesulfonate

: 1430738-23-0
(S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl) ( 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrol-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; triphenyl-arsane; silver(l) oxide; bis(benzonitrile)palladium(II) dichloride / 1,4-dioxane / 110 °C / Inert atmosphere

2: zinc; formic acid / ethanol / 0.5 h / 30 °C / Cooling with ice

With potassium phosphate; bis(benzonitrile)palladium(II) dichloride; formic acid; triphenyl-arsane; silver(l) oxide; zinc; In 1,4-dioxane; ethanol; 1: |Suzuki Coupling;

Reference yield:

: 1430738-05-8
(S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-1-(5-methoxy-2-nitro-4-((triisopropyls11yl)oxy)benzoyl)pyrrolidin-3-one

: 1430738-23-0
(S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl) ( 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrol-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / -50 °C

2: potassium phosphate; triphenyl-arsane; silver(l) oxide; bis(benzonitrile)palladium(II) dichloride / 1,4-dioxane / 110 °C / Inert atmosphere

3: zinc; formic acid / ethanol / 0.5 h / 30 °C / Cooling with ice

With 2,6-dimethylpyridine; potassium phosphate; bis(benzonitrile)palladium(II) dichloride; formic acid; triphenyl-arsane; silver(l) oxide; zinc; In 1,4-dioxane; ethanol; dichloromethane; 2: |Suzuki Coupling;