6-N-benzoyl-3′-azido-2′,5′-bis-O-(tert-butyldimethylsilyl)-3′-deoxyadenosine

Base Information

Chemical Name:6-N-benzoyl-3′-azido-2′,5′-bis-O-(tert-butyldimethylsilyl)-3′-deoxyadenosine
CAS No.:1142928-70-8
Molecular Formula:C₂₉H₄₄N₈O₄Si₂
Molecular Weight:624.891
Hs Code.:

Synonyms:6-N-benzoyl-3′-azido-2′,5′-bis-O-(tert-butyldimethylsilyl)-3′-deoxyadenosine

Suppliers and Price of 6-N-benzoyl-3′-azido-2′,5′-bis-O-(tert-butyldimethylsilyl)-3′-deoxyadenosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-N-benzoyl-3′-azido-2′,5′-bis-O-(tert-butyldimethylsilyl)-3′-deoxyadenosine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-N-benzoyl-3′-azido-2′,5′-bis-O-(tert-butyldimethylsilyl)-3′-deoxyadenosine

There total 6 articles about 6-N-benzoyl-3′-azido-2′,5′-bis-O-(tert-butyldimethylsilyl)-3′-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 695183-20-1
3'-azido-3'-deoxy-2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-adenosine

: 98-88-4
benzoyl chloride

: 1142928-70-8
6-N-benzoyl-3′-azido-2′,5′-bis-O-(tert-butyldimethylsilyl)-3′-deoxyadenosine

Guidance literature:: 3'-azido-3'-deoxy-2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-adenosine; benzoyl chloride; With pyridine; at 0 - 20 ℃;

With ammonium hydroxide; In water; at 0 - 20 ℃; for 4h;
DOI:10.1002/chem.200801563

Reference yield:

: 58-61-7
adenosine

: 1142928-70-8
6-N-benzoyl-3′-azido-2′,5′-bis-O-(tert-butyldimethylsilyl)-3′-deoxyadenosine

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 48 h / 20 °C

2: Dess-Martin periodane / dichloromethane / 48 h

3: acetic acid; sodium tetrahydroborate / tetrahydrofuran / 4 h / 0 - 20 °C

4: dichloromethane / 0.5 h / 0 °C

5: sodium azide / N,N-dimethyl-formamide / 2 h

6: pyridine / dichloromethane / 0 °C

With pyridine; sodium tetrahydroborate; sodium azide; Dess-Martin periodane; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 65109-11-7
2',5'-bis-O-(tert-butyldimethylsilyl)adenosine

: 1142928-70-8
6-N-benzoyl-3′-azido-2′,5′-bis-O-(tert-butyldimethylsilyl)-3′-deoxyadenosine

Guidance literature:: Multi-step reaction with 5 steps

1: Dess-Martin periodane / dichloromethane / 48 h

2: acetic acid; sodium tetrahydroborate / tetrahydrofuran / 4 h / 0 - 20 °C

3: dichloromethane / 0.5 h / 0 °C

4: sodium azide / N,N-dimethyl-formamide / 2 h

5: pyridine / dichloromethane / 0 °C

With pyridine; sodium tetrahydroborate; sodium azide; Dess-Martin periodane; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;