1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-indole

Base Information

Chemical Name:1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-indole
CAS No.:1373356-16-1
Molecular Formula:C₂₇H₂₅FN₄O₂S
Molecular Weight:488.586
Hs Code.:

Synonyms:1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-indole

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Chemical Property of 1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-indole

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Technology Process of 1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-indole

There total 10 articles about 1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1373356-64-9
(4-(azetidin-3-yl)piperidin-1-yl)(thiazol-2-yl)methanone

: 243467-60-9
(1-(4-fluorophenyl)-1H-indole-5-carboxylic acid)

: 1373356-16-1
1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-indole

Guidance literature:: (4-(azetidin-3-yl)piperidin-1-yl)(thiazol-2-yl)methanone; (1-(4-fluorophenyl)-1H-indole-5-carboxylic acid); With triethylamine; In dichloromethane; at 20 ℃; for 0.333333h;

With HATU; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 15854-87-2
4-iodopyridine

: 1373356-16-1
1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-indole

Guidance literature:: Multi-step reaction with 7 steps

1.1: chloro-trimethyl-silane; ethylene dibromide; zinc / N,N-dimethyl acetamide / 1.5 h / 20 - 65 °C / Inert atmosphere

1.2: 2 h / 80 °C / Inert atmosphere

2.1: acetonitrile / 1 h / 80 °C / Inert atmosphere

3.1: sodium tetrahydroborate; sodium hydrogencarbonate / ethanol / 1.17 h / 0 - 20 °C / Inert atmosphere

4.1: hydrogen; palladium(II) hydroxide / ethanol / 96 h / 20 °C / 2585.81 Torr / Inert atmosphere

5.1: triethylamine / dichloromethane / 0.33 h / 20 °C

5.2: 5 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

7.1: triethylamine / dichloromethane / 0.33 h / 20 °C

7.2: 20 h / 20 °C

With sodium tetrahydroborate; chloro-trimethyl-silane; hydrogen; palladium(II) hydroxide; sodium hydrogencarbonate; ethylene dibromide; triethylamine; trifluoroacetic acid; zinc; In ethanol; dichloromethane; N,N-dimethyl acetamide; acetonitrile;

Reference yield:

: 1373356-61-6
1-benzyl-4-(1-(tert-butoxycarbonyl)azetidin-3-yl)pyridin-1-ium bromide

: 1373356-16-1
1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-indole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; sodium hydrogencarbonate / ethanol / 1.17 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogen; palladium(II) hydroxide / ethanol / 96 h / 20 °C / 2585.81 Torr / Inert atmosphere

3.1: triethylamine / dichloromethane / 0.33 h / 20 °C

3.2: 5 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

5.1: triethylamine / dichloromethane / 0.33 h / 20 °C

5.2: 20 h / 20 °C

With sodium tetrahydroborate; hydrogen; palladium(II) hydroxide; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane;