243467-60-9

Usage

Molecular weight

273.26 g/mol
The mass of one mole of 1H-Indole-5-carboxylic acid, 1-(4-fluorophenyl)is 273.26 grams.

Derivative of indole

Heterocyclic organic compound
The compound is derived from indole, which is an organic compound containing a heterocyclic ring (a ring containing at least one non-carbon atom).

Carboxylic acid group

Functional group
The compound contains a carboxylic acid group (-COOH), which is a functional group consisting of a carbonyl group (C=O) and a hydroxyl group (-OH) bonded to the same carbon atom.

4-Fluorophenyl group

Functional group
The compound contains a 4-fluorophenyl group (a phenyl ring with a fluorine atom at the 4-position), which is a halogenated aryl group.

Building block for synthesis

Pharmaceutical, agrochemical, and other organic compounds
1H-Indole-5-carboxylic acid, 1-(4-fluorophenyl)is commonly used as a starting material or intermediate in the synthesis of various chemical products, including pharmaceuticals, agrochemicals, and other organic compounds.

Valuable intermediate

Production of various chemical products
Due to its unique properties and structure, 1H-Indole-5-carboxylic acid, 1-(4-fluorophenyl)is a valuable intermediate in the production of a wide range of chemical products.

Upstream product

• 138900-18-2 1-(4-fluorophenyl)-5-cyano-1H-indole 
• 1011-65-0 5-methoxycarbonylindole 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 352-34-1 4-fluoro-1-iodobenzene 
• 1144523-66-9 methyl 1-(4-fluorophenyl)-1H-indole-5-carboxylate 

Downstream Products

• 330944-13-3 N,N-dimethyl-1-(4-fluorophenyl)-1H-indole-5-carboxamide 
• 330944-14-4 1-(4-fluorophenyl)-N-methyl-1H-indole-5-carboxamide 
• 243467-59-6 1-(4-fluorophenyl)-5-(hydroxymethyl)-1H-indole 
• 243467-63-2 5-chloromethyl-1-(4-fluorophenyl)-1H-indole 
• 243467-64-3 5-(cyanomethyl)-1-(4-fluorophenyl)-1H-indole 
• 243467-62-1 1-(4-fluorophenyl)-5-[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)methyl]-1H-indole 
• 243467-61-0 1-(4-fluorophenyl)-5-[(2-methyl-2H-1,2,3,4-tetrazol-5-yl)methyl]-1H-indole 
• 243467-65-4 1-(4-fluorophenyl)-5-[(2H-1,2,3,4-tetrazol-5-yl)methyl]-1H-indole 
• 330944-19-9 5-(dimethylaminomethyl)-1-(4-fluorophenyl)-3-(piperidin-4-yl)-1H-indole 
• 330944-16-6 N,N-dimethyl-1-(4-fluorophenyl)-3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole-5-carboxamide 
• 330944-18-8 N,N-dimethyl-1-(4-fluorophenyl)-3-(piperidin-4-yl)-1H-indole-5-carboxamide 
• 330944-17-7 1-(4-fluorophenyl)-N-methyl-3-(piperidin-4-yl)-1H-indole-5-carboxamide 
• 330944-15-5 1-(4-fluorophenyl)-N-methyl-3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole-5-carboxamide 
• 243467-23-4 1-(4-fluoro-phenyl)-5-(1-methyl-1H-tetrazol-5-ylmethyl)-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole 

Relevant academic research and scientific papers

PIPERAZINE DERIVATIVES AS MAGL INHIBITORS

The invention provides new heterocyclic compounds having general Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, X, Y1 and Y2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

CRYSTALLINE HYDROCHLORIDE SALT OF (1- (4 -FLUOROPHENYL) - 1H - INDOL - 5 - YL) - (3- (4- (THIAZOLE - 2 - CARBONYL) PIPERAZIN- 1 - YL) AZ ETIDIN- 1 -YL) METHANONE AND ITS USE IN THE TREATMENT OF PAIN AND METABOLIC DISORDERS

The present invention relates to a crystalline hydrochloride salt of (l-(4-fluorophenyl)-lH-indol-5-yl)(3-(4-(thiazole-2-carbonyl)piper- azin-l-yl)azetidin-l-yl)methanone, Formula (I) methods of making said salt, pharmaceutical compositions contain? ing said salt, and the use of said salt in the treatment of pain and dis? eases that cause such pain, and metabolic disorders such as, obesity, hyperphagia, and diabetes.

MONOACYLGLYCEROL LIPASE INHIBITORS FOR THE TREATMENT OF METABOLIC DISEASES AND RELATED DISORDERS

Disclosed are compounds, compositions and methods for treating metabolic diseases, including obesity and diabetes, and for reducing weight gain. Such compounds are represented by formula (I) as follows: wherein Y and Z are defined herein.

PIPERIDIN-4-YL-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: wherein Y, Z, and R are defined herein.

DI-AZETIDINYL DIAMIDE AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Q and Z are defined herein.

OXOPIPERAZINE-AZETIDINE AMIDES AND OXODIAZEPINE-AZETIDINE AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (Ia) and Formula (Ib) as follows: wherein Y, Z, and n are defined herein; and wherein Yb and Zb are as defined herein.

AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I), wherein Y, Z, R1, and s are defined herein.

Synthesis and structure-affinity relationship investigations of 5-aminomethyl and 5-carbamoyl analogues of the antipsychotic sertindole. A new class of selective α1 adrenoceptor antagonists

A new class of selective α1 adrenoceptor antagonists derived from the antipsychotic drug sertindole is described. The most potent and selective compound 1-(2-{4-[5-aminomethyl-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl} ethyl)-2-imidazolid

5-heteroaryl substituted indoles

The present invention relates to compounds having general formula (I) as defined herein, or a pharmaceutically acceptable acid addition salt thereof. The compounds are selective α1-adrenoceptor ligands.