1-(4-{4-[4-(2-isopropoxyphenyl)-1-piperazinyl]-4-oxobutyl}benzoyl)piperidine

Base Information

Chemical Name:1-(4-{4-[4-(2-isopropoxyphenyl)-1-piperazinyl]-4-oxobutyl}benzoyl)piperidine
CAS No.:148827-13-8
Molecular Formula:C₂₉H₃₉N₃O₃
Molecular Weight:477.647
Hs Code.:

Synonyms:1-(4-{4-[4-(2-isopropoxyphenyl)-1-piperazinyl]-4-oxobutyl}benzoyl)piperidine

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Chemical Property of 1-(4-{4-[4-(2-isopropoxyphenyl)-1-piperazinyl]-4-oxobutyl}benzoyl)piperidine

Chemical Property:

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Technology Process of 1-(4-{4-[4-(2-isopropoxyphenyl)-1-piperazinyl]-4-oxobutyl}benzoyl)piperidine

There total 3 articles about 1-(4-{4-[4-(2-isopropoxyphenyl)-1-piperazinyl]-4-oxobutyl}benzoyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-89-4
piperidine

: 201230-82-2
carbon monoxide

: 148888-29-3
1-(4-Bromo-phenyl)-4-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-butan-1-one

: 148827-13-8
1-(4-{4-[4-(2-isopropoxyphenyl)-1-piperazinyl]-4-oxobutyl}benzoyl)piperidine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; In dimethyl sulfoxide; at 100 ℃; for 40h; under 760 Torr; 1.) DMSO, 100 deg C, 20 h, 2.) DMSO, 20 h, heating;
DOI:10.1021/jm970164z

Reference yield:

: 54013-91-1
2-(1-methylethoxy)phenyl-1-piperazine

: 148827-13-8
1-(4-{4-[4-(2-isopropoxyphenyl)-1-piperazinyl]-4-oxobutyl}benzoyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 23 percent / NaI, iPr₂EtNH / dimethylsulfoxide / 168 h

2: 1.25 g / Cl₂Pd(PPh₃)2 / dimethylsulfoxide / 40 h / 100 °C / 760 Torr / 1.) DMSO, 100 deg C, 20 h, 2.) DMSO, 20 h, heating

With bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine; sodium iodide; In dimethyl sulfoxide;
DOI:10.1021/jm970164z

Reference yield:

: 4559-96-0
1-(4-bromophenyl)-4-chlorobutan-1-one

: 148827-13-8
1-(4-{4-[4-(2-isopropoxyphenyl)-1-piperazinyl]-4-oxobutyl}benzoyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 23 percent / NaI, iPr₂EtNH / dimethylsulfoxide / 168 h

2: 1.25 g / Cl₂Pd(PPh₃)2 / dimethylsulfoxide / 40 h / 100 °C / 760 Torr / 1.) DMSO, 100 deg C, 20 h, 2.) DMSO, 20 h, heating

With bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine; sodium iodide; In dimethyl sulfoxide;
DOI:10.1021/jm970164z