(benzyloxycarbonyl)-Phe-Lys-N-ε-(tert-butoxycarbonyl)-PABC-(7-amino-4-methylcoumarin)

Base Information

Chemical Name:(benzyloxycarbonyl)-Phe-Lys-N-ε-(tert-butoxycarbonyl)-PABC-(7-amino-4-methylcoumarin)
CAS No.:1616957-61-9
Molecular Formula:C₄₆H₅₁N₅O₁₀
Molecular Weight:833.938
Hs Code.:

Synonyms:(benzyloxycarbonyl)-Phe-Lys-N-ε-(tert-butoxycarbonyl)-PABC-(7-amino-4-methylcoumarin)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (benzyloxycarbonyl)-Phe-Lys-N-ε-(tert-butoxycarbonyl)-PABC-(7-amino-4-methylcoumarin)

Chemical Property:

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Technology Process of (benzyloxycarbonyl)-Phe-Lys-N-ε-(tert-butoxycarbonyl)-PABC-(7-amino-4-methylcoumarin)

There total 6 articles about (benzyloxycarbonyl)-Phe-Lys-N-ε-(tert-butoxycarbonyl)-PABC-(7-amino-4-methylcoumarin) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1400743-57-8
(benzyloxycarbonyl)-Phe-Lys-N-ε-(tert-butoxycarbonyl)-(p-aminobenzyl)-OH

: 7-isocyanato-4-methylcoumarine

: 1616957-61-9
(benzyloxycarbonyl)-Phe-Lys-N-ε-(tert-butoxycarbonyl)-PABC-(7-amino-4-methylcoumarin)

Guidance literature:: In tetrahydrofuran; at 80 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm500544p

Reference yield:

: 623-04-1
4-aminobenzenemethanol

: 1616957-61-9
(benzyloxycarbonyl)-Phe-Lys-N-ε-(tert-butoxycarbonyl)-PABC-(7-amino-4-methylcoumarin)

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / tetrahydrofuran / 16 h / 20 °C

2: tetrahydrofuran / 2 h / 80 °C / Inert atmosphere

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In tetrahydrofuran;
DOI:10.1021/jm500544p

Reference yield:

: 2418-95-3
(S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid

: 1616957-61-9
(benzyloxycarbonyl)-Phe-Lys-N-ε-(tert-butoxycarbonyl)-PABC-(7-amino-4-methylcoumarin)

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / tetrahydrofuran; water / 16 h / 20 °C

2: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / tetrahydrofuran / 16 h / 20 °C

3: tetrahydrofuran / 2 h / 80 °C / Inert atmosphere

With sodium hydrogencarbonate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In tetrahydrofuran; water;
DOI:10.1021/jm500544p