C₂₂H₂₈O₂

Base Information

• Chemical Name: C₂₂H₂₈O₂
• CAS No.: 256464-88-7
• Molecular Formula: C₂₂H₂₈O₂
• Molecular Weight: 324.463
• Mol file: 256464-88-7.mol

Synonyms:C₂₂H₂₈O₂

Chemical Property of C₂₂H₂₈O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₈O₂

There total 4 articles about C₂₂H₂₈O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

benzyl bromide (100-39-0) + (3S,4R)-7-(benzyloxy)-3-methylhept-1-en-4-ol (256464-87-6) → C22H28O2 (256464-88-7)

Guidance literature:

(3S,4R)-7-(benzyloxy)-3-methylhept-1-en-4-ol; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

benzyl bromide; With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1021/ja057686l

Reference yield:

4-benzyloxybutanal (5470-84-8) → C22H28O2 (256464-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH; tetrabutylammonium iodide / dimethylformamide; various solvent(s) / 0.5 h / 0 °C

1.2: dimethylformamide; various solvent(s) / 0 - 20 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/ol990379y

Reference yield:

4-benzyloxy-butan-1-ol (4541-14-4) → C22H28O2 (256464-88-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 93 percent / oxalyl chloride; dimethyl sulfoxide; Et₃N / CH₂Cl₂ / -78 - 20 °C

2.1: NaH / tetrahydrofuran / 0 - 20 °C

2.2: 96 percent / tetrabutylammonium iodide / tetrahydrofuran / 12 h / 20 °C

With oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 1.1: Swern oxidation;

DOI:10.1021/ja057686l

upstream raw materials:

benzyl bromide

(3S,4R)-7-(benzyloxy)-3-methylhept-1-en-4-ol

4-benzyloxybutanal

4-benzyloxy-butan-1-ol

Downstream raw materials:

bistramide A

2-{3-[(2R,3S,6S,8S)-8-[(S)-4-(tert-butyldiphenylsilyloxy)-3-methylbutyl]-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]propyl}isoindoline-1,3-dione

3-((2R,3S,6S,8S)-8-[(S)-4-(tert-butyldiphenylsilyloxy)-3-methylbutyl]-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)propan-1-ol

C₂₂H₂₆Br₂O₂