methyl 2-[5-(2,4-difluorophenyl)-4-(6-hydroxy-5-nitro-2-pyridyl)-1H-imidazol-2-yl]-2-methyl-propanoate

Base Information

Chemical Name:methyl 2-[5-(2,4-difluorophenyl)-4-(6-hydroxy-5-nitro-2-pyridyl)-1H-imidazol-2-yl]-2-methyl-propanoate
CAS No.:1380094-31-4
Molecular Formula:C₁₉H₁₆F₂N₄O₅
Molecular Weight:418.357
Hs Code.:

Synonyms:methyl 2-[5-(2,4-difluorophenyl)-4-(6-hydroxy-5-nitro-2-pyridyl)-1H-imidazol-2-yl]-2-methyl-propanoate

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Chemical Property of methyl 2-[5-(2,4-difluorophenyl)-4-(6-hydroxy-5-nitro-2-pyridyl)-1H-imidazol-2-yl]-2-methyl-propanoate

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Technology Process of methyl 2-[5-(2,4-difluorophenyl)-4-(6-hydroxy-5-nitro-2-pyridyl)-1H-imidazol-2-yl]-2-methyl-propanoate

There total 7 articles about methyl 2-[5-(2,4-difluorophenyl)-4-(6-hydroxy-5-nitro-2-pyridyl)-1H-imidazol-2-yl]-2-methyl-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1380094-50-7
methyl 2-[4-(6-amino-5-nitro-2-pyridyl)-5-(2,4-difluorophenyl)-1H-imidazol-2-yl]-2-methyl-propanoate methanesulfonate

: 1380094-31-4
methyl 2-[5-(2,4-difluorophenyl)-4-(6-hydroxy-5-nitro-2-pyridyl)-1H-imidazol-2-yl]-2-methyl-propanoate

Guidance literature:: methyl 2-[4-(6-amino-5-nitro-2-pyridyl)-5-(2,4-difluorophenyl)-1H-imidazol-2-yl]-2-methyl-propanoate methanesulfonate; With sulfuric acid; sodium nitrite; In water; dimethyl sulfoxide; at 0 - 30 ℃; for 2h; Inert atmosphere;

With sodium dihydrogenphosphate; water; In water; dimethyl sulfoxide; at 0 - 25 ℃; for 3h;

Reference yield: 88.0%

: 1380094-30-3
methyl 2-[4-(6-amino-5-nitro-2-pyridyl)-5-(2,4-difluorophenyl)-1H-imidazol-2-yl]-2-methyl-propanoate

: 1380094-31-4
methyl 2-[5-(2,4-difluorophenyl)-4-(6-hydroxy-5-nitro-2-pyridyl)-1H-imidazol-2-yl]-2-methyl-propanoate

Guidance literature:: methyl 2-[4-(6-amino-5-nitro-2-pyridyl)-5-(2,4-difluorophenyl)-1H-imidazol-2-yl]-2-methyl-propanoate; With sulfuric acid; sodium nitrite; In water; dimethyl sulfoxide; at 0 ℃; for 0.583333h;

With sodium dihydrogenphosphate; In water; dimethyl sulfoxide; at 20 ℃; for 1h; pH=6;

Reference yield:

: 27048-04-0
2-amino-6-chloro-3-nitropyridine

: 1380094-31-4
methyl 2-[5-(2,4-difluorophenyl)-4-(6-hydroxy-5-nitro-2-pyridyl)-1H-imidazol-2-yl]-2-methyl-propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0.17 h / 0 - 5 °C / Inert atmosphere

1.2: 1 h / 30 °C

2.1: disodium hydrogenphosphate; potassium permanganate; sodium dihydrogenphosphate / water; acetone / 5 h / 0 - 15 °C / Inert atmosphere

2.2: 1 h / 15 - 20 °C

3.1: ammonium acetate / 1,4-dioxane / 1 h / 20 - 25 °C / Inert atmosphere

3.2: 14 h / 20 - 25 °C

3.3: 7 h / 10 - 25 °C

4.1: sodium nitrite; sulfuric acid / water; dimethyl sulfoxide / 2 h / 0 - 30 °C / Inert atmosphere

4.2: 3 h / 0 - 25 °C

With potassium permanganate; disodium hydrogenphosphate; sodium dihydrogenphosphate; sulfuric acid; ammonium acetate; triethylamine; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In 1,4-dioxane; water; dimethyl sulfoxide; acetone; acetonitrile;