4-(4’-chlorophenyl)-2-trichloromethylquinazoline

Base Information

• Chemical Name: 4-(4’-chlorophenyl)-2-trichloromethylquinazoline
• CAS No.: 1008132-68-0
• Molecular Formula: C₁₅H₈Cl₄N₂
• Molecular Weight: 358.054
• Mol file: 1008132-68-0.mol

Synonyms:4-(4’-chlorophenyl)-2-trichloromethylquinazoline

Chemical Property of 4-(4’-chlorophenyl)-2-trichloromethylquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4’-chlorophenyl)-2-trichloromethylquinazoline

There total 4 articles about 4-(4’-chlorophenyl)-2-trichloromethylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

4-chloro-2-(trichloromethyl)quinazoline (3137-63-1) + 4-Chlorophenylboronic acid (1679-18-1) → 4-(4’-chlorophenyl)-2-trichloromethylquinazoline (1008132-68-0)

Guidance literature:

With caesium carbonate; palladium diacetate; In N,N-dimethyl-formamide; at 150 ℃; for 2h; under 1125.11 Torr; microwave irradiation;

DOI:10.1016/j.bmcl.2007.10.027

Reference yield:

C11H12Cl2NO(1+)*Cl(1-) → 4-(4’-chlorophenyl)-2-trichloromethylquinazoline (1008132-68-0)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere; Darkness

With tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1002/ejoc.201402706

Reference yield:

C13H14Cl4N3O(1+)*Cl(1-) → 4-(4’-chlorophenyl)-2-trichloromethylquinazoline (1008132-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere; Darkness

With tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1002/ejoc.201402706

upstream raw materials:

4-chloro-2-(trichloromethyl)quinazoline

4-Chlorophenylboronic acid

N-(4-chlorobenzoyl)morpholine

Refernces

• 1、 Verhaeghe, Pierre,Azas, Nadine,Gasquet, Monique,Hutter, Sebastien,Ducros, Christophe,Laget, Michele,Rault, Sylvain,Rathelot, Pascal,Vanelle, Patrice. "Synthesis and antiplasmodial activity of new 4-aryl-2-trichloromethylquinazolines". . p. 396 - 401. Retrieved 2008/12/21.