ethyl (3R,5S)-1,5-dibenzyl-3-(2-nitrophenyl)-2-oxopyrrolidine-3-carboxylate

Base Information

Chemical Name:ethyl (3R,5S)-1,5-dibenzyl-3-(2-nitrophenyl)-2-oxopyrrolidine-3-carboxylate
CAS No.:1396762-95-0
Molecular Formula:C₂₇H₂₆N₂O₅
Molecular Weight:458.514
Hs Code.:

Synonyms:ethyl (3R,5S)-1,5-dibenzyl-3-(2-nitrophenyl)-2-oxopyrrolidine-3-carboxylate

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Chemical Property of ethyl (3R,5S)-1,5-dibenzyl-3-(2-nitrophenyl)-2-oxopyrrolidine-3-carboxylate

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Technology Process of ethyl (3R,5S)-1,5-dibenzyl-3-(2-nitrophenyl)-2-oxopyrrolidine-3-carboxylate

There total 3 articles about ethyl (3R,5S)-1,5-dibenzyl-3-(2-nitrophenyl)-2-oxopyrrolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1396762-90-5
diethyl (S)-2-(2-((benzyloxycarbonyl)amino)-3-phenylpropyl)-2-(2-nitrophenyl)malonate

: 100-39-0
benzyl bromide

: 1396762-95-0
ethyl (3R,5S)-1,5-dibenzyl-3-(2-nitrophenyl)-2-oxopyrrolidine-3-carboxylate

Guidance literature:: diethyl (S)-2-(2-((benzyloxycarbonyl)amino)-3-phenylpropyl)-2-(2-nitrophenyl)malonate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at 20 ℃; for 5h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol302176z DOI:10.1021/ol302176z

Reference yield:

: 1007121-75-6
(S)-3-(benzyloxycarbonyl)-4-benzyl-[1,2,3]oxathiazolidine 2,2-dioxide

: 1396762-95-0
ethyl (3R,5S)-1,5-dibenzyl-3-(2-nitrophenyl)-2-oxopyrrolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C / Inert atmosphere

1.2: 13 h / 65 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2.2: 5 h / 20 °C / Inert atmosphere

With sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; mineral oil;
DOI:10.1021/ol302176z DOI:10.1021/ol302176z

Reference yield:

: 10565-14-7
Diethyl 2-(2-nitrophenyl)propanedioate

: 1396762-95-0
ethyl (3R,5S)-1,5-dibenzyl-3-(2-nitrophenyl)-2-oxopyrrolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C / Inert atmosphere

1.2: 13 h / 65 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2.2: 5 h / 20 °C / Inert atmosphere

With sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; mineral oil;
DOI:10.1021/ol302176z DOI:10.1021/ol302176z