diethyl (S)-2-(2-((benzyloxycarbonyl)amino)-3-phenylpropyl)-2-(2-nitrophenyl)malonate

Base Information

Chemical Name:diethyl (S)-2-(2-((benzyloxycarbonyl)amino)-3-phenylpropyl)-2-(2-nitrophenyl)malonate
CAS No.:1396762-90-5
Molecular Formula:C₃₀H₃₂N₂O₈
Molecular Weight:548.593
Hs Code.:

Synonyms:diethyl (S)-2-(2-((benzyloxycarbonyl)amino)-3-phenylpropyl)-2-(2-nitrophenyl)malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl (S)-2-(2-((benzyloxycarbonyl)amino)-3-phenylpropyl)-2-(2-nitrophenyl)malonate

Chemical Property:

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Technology Process of diethyl (S)-2-(2-((benzyloxycarbonyl)amino)-3-phenylpropyl)-2-(2-nitrophenyl)malonate

There total 1 articles about diethyl (S)-2-(2-((benzyloxycarbonyl)amino)-3-phenylpropyl)-2-(2-nitrophenyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1007121-75-6
(S)-3-(benzyloxycarbonyl)-4-benzyl-[1,2,3]oxathiazolidine 2,2-dioxide

: 10565-14-7
Diethyl 2-(2-nitrophenyl)propanedioate

: 1396762-90-5
diethyl (S)-2-(2-((benzyloxycarbonyl)amino)-3-phenylpropyl)-2-(2-nitrophenyl)malonate

Guidance literature:: Diethyl 2-(2-nitrophenyl)propanedioate; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.166667h; Inert atmosphere;

(S)-3-(benzyloxycarbonyl)-4-benzyl-[1,2,3]oxathiazolidine 2,2-dioxide; In tetrahydrofuran; mineral oil; at 65 ℃; for 13h; Inert atmosphere;
DOI:10.1021/ol302176z DOI:10.1021/ol302176z

Reference yield:

: 1396762-90-5
diethyl (S)-2-(2-((benzyloxycarbonyl)amino)-3-phenylpropyl)-2-(2-nitrophenyl)malonate

: 1396762-94-9
ethyl (-)-(3R,5S)-5-benzyl-3-(2-nitrophenyl)-2-oxopyrrolidine-3-carboxylate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol302176z DOI:10.1021/ol302176z

Reference yield:

: 1396762-90-5
diethyl (S)-2-(2-((benzyloxycarbonyl)amino)-3-phenylpropyl)-2-(2-nitrophenyl)malonate

: 100-39-0
benzyl bromide

: 1396762-95-0
ethyl (3R,5S)-1,5-dibenzyl-3-(2-nitrophenyl)-2-oxopyrrolidine-3-carboxylate

Guidance literature:: diethyl (S)-2-(2-((benzyloxycarbonyl)amino)-3-phenylpropyl)-2-(2-nitrophenyl)malonate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at 20 ℃; for 5h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol302176z DOI:10.1021/ol302176z