3’-aminodocetaxel formate

Base Information

• Chemical Name: 3’-aminodocetaxel formate
• CAS No.: 1383572-41-5
• Molecular Formula: CH₂O₂*C₃₈H₄₅NO₁₂
• Molecular Weight: 753.8
• Mol file: 1383572-41-5.mol

Synonyms:3’-aminodocetaxel formate

Chemical Property of 3’-aminodocetaxel formate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3’-aminodocetaxel formate

There total 1 articles about 3’-aminodocetaxel formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formic acid (64-18-6) + Docetaxel (114915-20-7,114977-28-5,114977-29-6,133577-32-9,133577-33-0) → 3’-aminodocetaxel formate (1383572-41-5)

Guidance literature:

at 5 ℃;

Reference yield: 30.0%

3’-aminodocetaxel formate (1383572-41-5) + C22H34N2O9 → C56H74N2O18

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; Darkness;

DOI:10.1002/chem.202001290

Reference yield: 27.0%

octane-1,8-dioic acid (505-48-6) + 3’-aminodocetaxel formate (1383572-41-5) → 3’-(5-carboxyheptanoylamino)docetaxel

Guidance literature:

octane-1,8-dioic acid; With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; for 0.0833333h;

3’-aminodocetaxel formate; In dimethyl sulfoxide; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2021.128252

upstream raw materials:

formic acid

Docetaxel

Downstream raw materials:

d₉-docetaxel