3,4-O-dimethoxycarbonyl caffeic acid chloride

Base Information

• Chemical Name: 3,4-O-dimethoxycarbonyl caffeic acid chloride
• CAS No.: 16180-95-3
• Molecular Formula: C₁₃H₁₁ClO₇
• Molecular Weight: 314.679
• Mol file: 16180-95-3.mol

Synonyms:3,4-O-dimethoxycarbonyl caffeic acid chloride

Chemical Property of 3,4-O-dimethoxycarbonyl caffeic acid chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 3,4-O-dimethoxycarbonyl caffeic acid chloride

There total 7 articles about 3,4-O-dimethoxycarbonyl caffeic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3,4-O-dimethoxycarbonyl caffeic acid (18959-40-5) → 3,4-O-dimethoxycarbonyl caffeic acid chloride (16180-95-3)

Guidance literature:

With thionyl chloride; at 90 ℃; for 2h;

DOI:10.1016/j.foodchem.2014.07.080

Reference yield:

caffeic acid (331-39-5,501-16-6) → 3,4-O-dimethoxycarbonyl caffeic acid chloride (16180-95-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1N aq. NaOH / 0 °C

2: thionyl chloride / 80 - 90 °C

With sodium hydroxide; thionyl chloride;

DOI:10.1021/jm9804735

Reference yield:

3,4-bis[(methoxycarbonyl)oxy]cinnamic acid (861897-00-9) → 3,4-di-O-(methoxycarbonyl)caffeoyl chloride (16180-95-3)

Guidance literature:

With oxalyl dichloride; In toluene; at 60 ℃; for 1.5h;

DOI:10.1016/j.bmc.2005.04.049

upstream raw materials:

3,4-O-dimethoxycarbonyl caffeic acid

caffeic acid

oxalyl dichloride

3,4-bis[(methoxycarbonyl)oxy]cinnamic acid

Downstream raw materials:

1,4-bisbutanediol