(E)-2-(2-(2,4-dichlorostyryl)-5-nitro-1H-imidazol-1-yl) ethanol

Base Information

• Chemical Name: (E)-2-(2-(2,4-dichlorostyryl)-5-nitro-1H-imidazol-1-yl) ethanol
• CAS No.: 1584803-92-8
• Molecular Formula: C₁₃H₁₁Cl₂N₃O₃
• Molecular Weight: 328.155
• Mol file: 1584803-92-8.mol

Synonyms:(E)-2-(2-(2,4-dichlorostyryl)-5-nitro-1H-imidazol-1-yl) ethanol

Chemical Property of (E)-2-(2-(2,4-dichlorostyryl)-5-nitro-1H-imidazol-1-yl) ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (E)-2-(2-(2,4-dichlorostyryl)-5-nitro-1H-imidazol-1-yl) ethanol

There total 1 articles about (E)-2-(2-(2,4-dichlorostyryl)-5-nitro-1H-imidazol-1-yl) ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.5%

2,4-dichlorobenzaldeyhde (874-42-0) + metronidazole (443-48-1) → (E)-2-(2-(2,4-dichlorostyryl)-5-nitro-1H-imidazol-1-yl) ethanol (1584803-92-8)

Guidance literature:

With sodium methylate; In methanol; dimethyl sulfoxide; at 20 ℃;

DOI:10.1016/j.ejmech.2014.02.004

Reference yield: 72.1%

(E)-2-(2-(2,4-dichlorostyryl)-5-nitro-1H-imidazol-1-yl) ethanol (1584803-92-8) + p-toluenesulfonyl chloride (98-59-9) → (Z)-2-(2-(2,4-dichlorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl-4-methylbenzenesulfonate

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1016/j.ejmech.2014.07.082

Reference yield:

(E)-2-(2-(2,4-dichlorostyryl)-5-nitro-1H-imidazol-1-yl) ethanol (1584803-92-8) → 2-(2-(2,4-dichlorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 1H-indole-3-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 5 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2014.07.082

upstream raw materials:

2,4-dichlorobenzaldeyhde

metronidazole