(S)-(+)-2-(N-diphenylphosphinyl)amino-3-phenylpropiophenone

Base Information

• Chemical Name: (S)-(+)-2-(N-diphenylphosphinyl)amino-3-phenylpropiophenone
• CAS No.: 189823-50-5
• Molecular Formula: C₂₇H₂₄NO₂P
• Molecular Weight: 425.467
• Mol file: 189823-50-5.mol

Synonyms:(S)-(+)-2-(N-diphenylphosphinyl)amino-3-phenylpropiophenone

Chemical Property of (S)-(+)-2-(N-diphenylphosphinyl)amino-3-phenylpropiophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(+)-2-(N-diphenylphosphinyl)amino-3-phenylpropiophenone

There total 6 articles about (S)-(+)-2-(N-diphenylphosphinyl)amino-3-phenylpropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

phenylmagnesium bromide (100-58-3) + (1S,2S)-(+)-pseudoephedrine N-diphenylphosphinyl-L-phenylalaninamide (189823-49-2) → (S)-(+)-2-(N-diphenylphosphinyl)amino-3-phenylpropiophenone (189823-50-5)

Guidance literature:

In tetrahydrofuran; for 12h; -78 deg C to r.t.;

DOI:10.1016/S0040-4039(97)00302-X

Reference yield: 79.0%

phenylmagnesium chloride (100-59-4) + (1S,2S)-(+)-pseudoephedrine N-diphenylphosphinyl-L-phenylalaninamide (189823-49-2) → (S)-(+)-2-(N-diphenylphosphinyl)amino-3-phenylpropiophenone (189823-50-5)

Guidance literature:

In tetrahydrofuran; for 12h; Ambient temperature;

DOI:10.1016/S0040-4020(98)00474-8

Reference yield:

Nα-diphenylphosphinoylphenylalanine (62056-93-3) → (S)-(+)-2-(N-diphenylphosphinyl)amino-3-phenylpropiophenone (189823-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / triethylamine, pivaloyl chloride / CH₂Cl₂ / 16 h / Ambient temperature

2: 79 percent / tetrahydrofuran / 12 h / Ambient temperature

With pivaloyl chloride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4020(98)00474-8

upstream raw materials:

phenylmagnesium bromide

(1S,2S)-(+)-pseudoephedrine N-diphenylphosphinyl-L-phenylalaninamide

phenylmagnesium chloride

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride