2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol

Base Information

Chemical Name:2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol
CAS No.:1361570-65-1
Molecular Formula:C₁₇H₁₀F₂N₆O₃
Molecular Weight:384.302
Hs Code.:

Synonyms:2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol

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Chemical Property of 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol

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Technology Process of 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol

There total 12 articles about 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1350653-28-9
5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide acetic acid

: 20139-83-7
ethyl 3-(dimethylamino)-2-nitroacrylate

: 1361570-65-1
2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol

Guidance literature:: In para-xylene; for 5h; Reflux;

Reference yield:

: 1350653-24-5
5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine

: 1361570-65-1
2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethyl sulfoxide / 2 h / 150 °C

2.1: sodium methylate / methanol / 2 h / 20 °C

2.2: Reflux

3.1: para-xylene / 5 h / Reflux

With sodium methylate; In methanol; para-xylene; dimethyl sulfoxide;

Reference yield:

: 1350653-26-7
5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile

: 1361570-65-1
2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium methylate / methanol / 2 h / 20 °C

1.2: Reflux

2.1: para-xylene / 5 h / Reflux

With sodium methylate; In methanol; para-xylene;