(S)-4-{(S)-1-[(Benzyloxy-{3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propoxy}-phosphorylmethyl)-carbamoyl]-ethylcarbamoyl}-2-benzyloxycarbonylamino-butyric acid benzyl ester

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Chemical Name:(S)-4-{(S)-1-[(Benzyloxy-{3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propoxy}-phosphorylmethyl)-carbamoyl]-ethylcarbamoyl}-2-benzyloxycarbonylamino-butyric acid benzyl ester
CAS No.:197971-43-0
Molecular Formula:C₅₄H₆₄N₅O₁₃P
Molecular Weight:1022.1
Hs Code.:

(S)-4-{(S)-1-[(Benzyloxy-{3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propoxy}-phosphorylmethyl)-carbamoyl]-ethylcarbamoyl}-2-benzyloxycarbonylamino-butyric acid benzyl ester

Synonyms:(S)-4-{(S)-1-[(Benzyloxy-{3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propoxy}-phosphorylmethyl)-carbamoyl]-ethylcarbamoyl}-2-benzyloxycarbonylamino-butyric acid benzyl ester

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Chemical Property of (S)-4-{(S)-1-[(Benzyloxy-{3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propoxy}-phosphorylmethyl)-carbamoyl]-ethylcarbamoyl}-2-benzyloxycarbonylamino-butyric acid benzyl ester

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Technology Process of (S)-4-{(S)-1-[(Benzyloxy-{3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propoxy}-phosphorylmethyl)-carbamoyl]-ethylcarbamoyl}-2-benzyloxycarbonylamino-butyric acid benzyl ester

There total 9 articles about (S)-4-{(S)-1-[(Benzyloxy-{3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propoxy}-phosphorylmethyl)-carbamoyl]-ethylcarbamoyl}-2-benzyloxycarbonylamino-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: (S)-2-Benzyloxycarbonylamino-4-((S)-1-carboxy-ethylcarbamoyl)-butyric acid benzyl ester

: 197971-41-8
Aminomethyl-phosphonic acid benzyl ester 3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propyl ester

: 197971-43-0
(S)-4-{(S)-1-[(Benzyloxy-{3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propoxy}-phosphorylmethyl)-carbamoyl]-ethylcarbamoyl}-2-benzyloxycarbonylamino-butyric acid benzyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1.) 0 deg C, 15 min, 2.) RT, 1.5 h;
DOI:10.1021/jm970414b

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 197971-43-0
(S)-4-{(S)-1-[(Benzyloxy-{3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propoxy}-phosphorylmethyl)-carbamoyl]-ethylcarbamoyl}-2-benzyloxycarbonylamino-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N, DMAP / CH₂Cl₂ / 24 h / Ambient temperature

2: 81 percent / TBAF, AcOH / tetrahydrofuran / 6 h / Ambient temperature

3: DMAP / CH₂Cl₂ / Ambient temperature

4: 85 percent / hydrazine monohydrate / methanol / 24 h / Ambient temperature

5: 81 percent / BOP, DIEA / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) RT, 1.5 h

With dmap; tetrabutyl ammonium fluoride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; hydrazine hydrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm970414b

Reference yield:

: C₁₆H₁₃ClNO₄P

: 197971-43-0
(S)-4-{(S)-1-[(Benzyloxy-{3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propoxy}-phosphorylmethyl)-carbamoyl]-ethylcarbamoyl}-2-benzyloxycarbonylamino-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DMAP / CH₂Cl₂ / Ambient temperature

2: 85 percent / hydrazine monohydrate / methanol / 24 h / Ambient temperature

3: 81 percent / BOP, DIEA / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) RT, 1.5 h

With dmap; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1021/jm970414b