N-fluorenylmethyloxycarbonyl-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzylamine

Base Information

Chemical Name:N-fluorenylmethyloxycarbonyl-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzylamine
CAS No.:171082-07-8
Molecular Formula:C₄₅H₄₁NO₆
Molecular Weight:691.824
Hs Code.:

Synonyms:N-fluorenylmethyloxycarbonyl-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-fluorenylmethyloxycarbonyl-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzylamine

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Technology Process of N-fluorenylmethyloxycarbonyl-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzylamine

There total 7 articles about N-fluorenylmethyloxycarbonyl-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 188257-47-8
(3-(aminomethyl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)phenyl)methanol

: 171082-07-8
N-fluorenylmethyloxycarbonyl-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzylamine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.666667h;
DOI:10.1080/15257779908043075

Reference yield:

: 618-88-2
5-nitrobenzene-1,3-dicarboxylic acid

: 171082-07-8
N-fluorenylmethyloxycarbonyl-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzylamine

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / H₂ / Pd/C / methanol / 1 h / 20 °C / 760 Torr

2: 82 percent / conc. H₂SO₄ / 16 h / Heating

3: 82 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

4: 1.) aq. NaNO₂, aq. HCl / 1.) -5 deg C, 30 min, 2.) H₂O, 0 deg C, 2 h

5: 52.3 percent / pyridine / 20 °C

6: 79 percent / LiAlH₄ / diethyl ether

7: 68 percent / iPr₂NEt / dimethylformamide / 0.67 h / 0 - 20 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; hydrogen; N-ethyl-N,N-diisopropylamine; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1080/15257779908043075

Reference yield:

: 99-31-0
5-aminoisophthalic acid

: 171082-07-8
N-fluorenylmethyloxycarbonyl-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / conc. H₂SO₄ / 16 h / Heating

2: 82 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

3: 1.) aq. NaNO₂, aq. HCl / 1.) -5 deg C, 30 min, 2.) H₂O, 0 deg C, 2 h

4: 52.3 percent / pyridine / 20 °C

5: 79 percent / LiAlH₄ / diethyl ether

6: 68 percent / iPr₂NEt / dimethylformamide / 0.67 h / 0 - 20 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1080/15257779908043075