2-(1,3-Dioxolan-2-yl)-4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]bromobenzene

Base Information

• Chemical Name: 2-(1,3-Dioxolan-2-yl)-4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]bromobenzene
• CAS No.: 254744-55-3
• Molecular Formula: C₂₁H₂₇BrN₂O₃
• Molecular Weight: 435.361
• Mol file: 254744-55-3.mol

Synonyms:2-(1,3-Dioxolan-2-yl)-4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]bromobenzene

Chemical Property of 2-(1,3-Dioxolan-2-yl)-4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]bromobenzene

Chemical Property:

• Boiling Point: 533.3±60.0 °C(Predicted)
• Density: 1.45±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

3-(4-Bromo-3-(1,3-dioxolan-2-yl)benzyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1,3-Dioxolan-2-yl)-4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]bromobenzene

There total 5 articles about 2-(1,3-Dioxolan-2-yl)-4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]bromobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride → 2-(1,3-Dioxolan-2-yl)-4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]bromobenzene (254744-55-3)

Guidance literature:

In N,N-dimethyl-formamide; mineral oil;

Reference yield:

2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one (138402-05-8) + 2-[(2'-bromo-5'-bromomethyl)phenyl]-1,3-dioxolane (254744-54-2) → 2-(1,3-Dioxolan-2-yl)-4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]bromobenzene (254744-55-3)

Guidance literature:

2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.25h;

2-[(2'-bromo-5'-bromomethyl)phenyl]-1,3-dioxolane; In N,N-dimethyl-formamide; for 14h; Further stages.;

DOI:10.1021/jm020138n

Reference yield:

2-[(2'-bromo-5'-hydroxymethyl)phenyl]-1,3-dioxolane (160313-48-4) → 2-(1,3-Dioxolan-2-yl)-4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]bromobenzene (254744-55-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 31.1 g / carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 2 h / 0 °C

2.1: sodium hydride / dimethylformamide / 0.25 h / 0 - 20 °C

2.2: 42.7 g / dimethylformamide / 14 h

With carbon tetrabromide; sodium hydride; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm020138n

upstream raw materials:

2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one

2-[(2'-bromo-5'-bromomethyl)phenyl]-1,3-dioxolane

2-[(2'-bromo-5'-cyano)phenyl]-1,3-dioxolane

2-[(2'-bromo-5'-hydroxymethyl)phenyl]-1,3-dioxolane

Downstream raw materials:

4-{[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-amino}-2,2-dimethyl-butyric acid

4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-formylbromobenzene