(2S)-2-amino-1-(2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yl)-3-phenylpropan-1-one trifluoroacetate

Base Information

• Chemical Name: (2S)-2-amino-1-(2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yl)-3-phenylpropan-1-one trifluoroacetate
• CAS No.: 1352201-73-0
• Molecular Formula: C₂HF₃O₂*C₁₅H₁₈N₂O₂
• Molecular Weight: 372.344
• Mol file: 1352201-73-0.mol

Synonyms:(2S)-2-amino-1-(2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yl)-3-phenylpropan-1-one trifluoroacetate

Chemical Property of (2S)-2-amino-1-(2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yl)-3-phenylpropan-1-one trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-2-amino-1-(2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yl)-3-phenylpropan-1-one trifluoroacetate

There total 5 articles about (2S)-2-amino-1-(2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yl)-3-phenylpropan-1-one trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl [(2S)-1-(2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yl)-1-oxo-3-phenylpropan-2-yl]carbamate + trifluoroacetic acid (76-05-1) → (2S)-2-amino-1-(2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yl)-3-phenylpropan-1-one trifluoroacetate (1352201-73-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

2-oxa-3-azabicyclo[2.2.2]oct-5-ene (7160-44-3) + sodium hydrogencarbonate (144-55-8) + Boc-Phe-ONSu (3674-06-4) + citric acid (77-92-9,906507-37-7) → (2S)-2-amino-1-(2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yl)-3-phenylpropan-1-one trifluoroacetate (1352201-73-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

2-oxa-3-azabicyclo[2.2.2]oct-5-ene (7160-44-3) → (2S)-2-amino-1-(2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yl)-3-phenylpropan-1-one trifluoroacetate (1352201-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2: dichloromethane / 0.5 h / 20 °C

With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2-oxa-3-azabicyclo[2.2.2]oct-5-ene

sodium hydrogencarbonate

Boc-Phe-ONSu

citric acid