ethyl 3-(2-nitrobenzoyl)-1-propionyl-Δ²-pyrazoline-5-carboxylate

Base Information

• Chemical Name: ethyl 3-(2-nitrobenzoyl)-1-propionyl-Δ²-pyrazoline-5-carboxylate
• CAS No.: 710300-77-9
• Molecular Formula: C₁₆H₁₇N₃O₆
• Molecular Weight: 347.327
• Mol file: 710300-77-9.mol

Synonyms:ethyl 3-(2-nitrobenzoyl)-1-propionyl-Δ²-pyrazoline-5-carboxylate

Chemical Property of ethyl 3-(2-nitrobenzoyl)-1-propionyl-Δ²-pyrazoline-5-carboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of ethyl 3-(2-nitrobenzoyl)-1-propionyl-Δ²-pyrazoline-5-carboxylate

There total 2 articles about ethyl 3-(2-nitrobenzoyl)-1-propionyl-Δ²-pyrazoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

propionyl chloride (79-03-8) + 3-(2-nitrobenzoyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid ethyl ester (710300-13-3) → ethyl 3-(2-nitrobenzoyl)-1-propionyl-Δ2-pyrazoline-5-carboxylate (710300-77-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.tet.2004.03.013

Reference yield:

1-(2-nitrophenyl)prop-2-en-1-one (68165-36-6) → ethyl 3-(2-nitrobenzoyl)-1-propionyl-Δ2-pyrazoline-5-carboxylate (710300-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / pyridine / acetonitrile / 10 h

2: 98 percent / triethylamine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2004.03.013

Reference yield: 95.0%

ethyl 3-(2-nitrobenzoyl)-1-propionyl-Δ2-pyrazoline-5-carboxylate (710300-77-9) → ethyl 3-(2-aminobenzoyl)-1-propionyl-Δ2-pyrazoline-5-carboxylate

Guidance literature:

With iron; iron(II) sulfate; In water; for 3h; Heating;

DOI:10.1016/j.tet.2004.03.013

upstream raw materials:

propionyl chloride

3-(2-nitrobenzoyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid ethyl ester

1-(2-nitrophenyl)prop-2-en-1-one