(S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N₆,N₆-dimethyladenosine cyclic 3',5'-N-benzylphosphoramidate

Base Information

• Chemical Name: (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N₆,N₆-dimethyladenosine cyclic 3',5'-N-benzylphosphoramidate
• CAS No.: 1351069-94-7
• Molecular Formula: C₂₉H₃₉N₆O₆PSi
• Molecular Weight: 626.725
• Mol file: 1351069-94-7.mol

Synonyms:(S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N₆,N₆-dimethyladenosine cyclic 3',5'-N-benzylphosphoramidate

Chemical Property of (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N₆,N₆-dimethyladenosine cyclic 3',5'-N-benzylphosphoramidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N₆,N₆-dimethyladenosine cyclic 3',5'-N-benzylphosphoramidate

There total 2 articles about (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N₆,N₆-dimethyladenosine cyclic 3',5'-N-benzylphosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-6-desamino-6-(1,2,4-triazol-4-yl)adenosine cyclic 3',5'-N-benzylphosphoramidate (1351069-92-5) + dimethyl amine (124-40-3) → (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N6,N6-dimethyladenosine cyclic 3',5'-N-benzylphosphoramidate (1351069-94-7)

Guidance literature:

With pyridine; In water; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2011.10.003

Reference yield:

(SP)-2'-O-(tert-butyldimethylsilyl)-8-(2-furyl)adenosine-3',5'-cyclic N-benzylphosphoramidate (872025-84-8) → (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N6,N6-dimethyladenosine cyclic 3',5'-N-benzylphosphoramidate (1351069-94-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 20 h / 95 °C

2: pyridine / water / 4 h / 20 °C

With pyridine; In water;

DOI:10.1016/j.ejmech.2011.10.003

upstream raw materials:

(S_P)-2'-O-(tert-butyldimethylsilyl)-8-(2-furyl)adenosine-3',5'-cyclic N-benzylphosphoramidate

(S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-6-desamino-6-(1,2,4-triazol-4-yl)adenosine cyclic 3',5'-N-benzylphosphoramidate

dimethyl amine