(S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-6-desamino-6-(1,2,4-triazol-4-yl)adenosine cyclic 3',5'-N-benzylphosphoramidate

Base Information

• Chemical Name: (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-6-desamino-6-(1,2,4-triazol-4-yl)adenosine cyclic 3',5'-N-benzylphosphoramidate
• CAS No.: 1351069-92-5
• Molecular Formula: C₂₉H₃₅N₈O₆PSi
• Molecular Weight: 650.706
• Mol file: 1351069-92-5.mol

Synonyms:(S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-6-desamino-6-(1,2,4-triazol-4-yl)adenosine cyclic 3',5'-N-benzylphosphoramidate

Chemical Property of (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-6-desamino-6-(1,2,4-triazol-4-yl)adenosine cyclic 3',5'-N-benzylphosphoramidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-6-desamino-6-(1,2,4-triazol-4-yl)adenosine cyclic 3',5'-N-benzylphosphoramidate

There total 1 articles about (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-6-desamino-6-(1,2,4-triazol-4-yl)adenosine cyclic 3',5'-N-benzylphosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

(SP)-2'-O-(tert-butyldimethylsilyl)-8-(2-furyl)adenosine-3',5'-cyclic N-benzylphosphoramidate (872025-84-8) + N,N'-bis(dimethylaminomethylene)hydrazine (16114-05-9,291307-12-5) + {N'-[(dimethylamino)methylene]-N,N-dimethylhydrazonoformamide dihydrochloride} (16227-06-8) → (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-6-desamino-6-(1,2,4-triazol-4-yl)adenosine cyclic 3',5'-N-benzylphosphoramidate (1351069-92-5)

Guidance literature:

With pyridine; at 95 ℃; for 20h;

DOI:10.1016/j.ejmech.2011.10.003

Reference yield: 90.0%

(S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-6-desamino-6-(1,2,4-triazol-4-yl)adenosine cyclic 3',5'-N-benzylphosphoramidate (1351069-92-5) + dimethyl amine (124-40-3) → (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N6,N6-dimethyladenosine cyclic 3',5'-N-benzylphosphoramidate (1351069-94-7)

Guidance literature:

With pyridine; In water; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2011.10.003

Reference yield: 88.0%

(S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-6-desamino-6-(1,2,4-triazol-4-yl)adenosine cyclic 3',5'-N-benzylphosphoramidate (1351069-92-5) + methylamine (74-89-5) → (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N6-methyladenosine cyclic 3',5'-N-benzylphosphoramidate (1351069-96-9)

Guidance literature:

With pyridine; In water; at 20 ℃; for 20h;

DOI:10.1016/j.ejmech.2011.10.003

upstream raw materials:

(S_P)-2'-O-(tert-butyldimethylsilyl)-8-(2-furyl)adenosine-3',5'-cyclic N-benzylphosphoramidate

N,N'-bis(dimethylaminomethylene)hydrazine

{N'-[(dimethylamino)methylene]-N,N-dimethylhydrazonoformamide dihydrochloride}

Downstream raw materials:

C₂₁H₂₀N₅O₆PS

(R(P))-N₆-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid tri-n-butylammonium salt

(R(P))-N₆-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid sodium salt

(S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N₆,N₆-dimethyladenosine cyclic 3',5'-N-benzylphosphoramidate