(S)-N-((R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Base Information

Chemical Name:(S)-N-((R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide
CAS No.:1453069-83-4
Molecular Formula:C₁₄H₁₉BrF₃NOS
Molecular Weight:386.276
Hs Code.:

Synonyms:(S)-N-((R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-((R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

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Technology Process of (S)-N-((R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

There total 6 articles about (S)-N-((R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1453069-81-2
(S)-N-((R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

: 74-88-4
methyl iodide

: 1453069-83-4
(S)-N-((R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Guidance literature:: (S)-N-((R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide; With lithium hexamethyldisilazane; In tetrahydrofuran; at -60 ℃; for 0.25h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at -60 - 20 ℃; for 1h;

Reference yield:

: 328-67-6
3-bromo-5-(trifluoromethyl)benzoic acid

: 1453069-83-4
(S)-N-((R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 °C

2.1: triethylamine / dichloromethane / 1 h / 0 °C

3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.33 h / -40 - 20 °C

4.1: titanium(IV) isopropylate / tetrahydrofuran / 6 h / 0 - 20 °C

5.1: dichloromethane; tetrahydrofuran / 2 h / -40 - 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -60 °C / Inert atmosphere

6.2: 1 h / -60 - 20 °C

With titanium(IV) isopropylate; oxalyl dichloride; diisobutylaluminium hydride; triethylamine; N,N-dimethyl-formamide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 880652-44-8
3-bromo-N-methoxy-N-methyl-5-(trifluoromethyl)benzamide

: 1453069-83-4
(S)-N-((R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.33 h / -40 - 20 °C

2.1: titanium(IV) isopropylate / tetrahydrofuran / 6 h / 0 - 20 °C

3.1: dichloromethane; tetrahydrofuran / 2 h / -40 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -60 °C / Inert atmosphere

4.2: 1 h / -60 - 20 °C

With titanium(IV) isopropylate; diisobutylaluminium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; toluene;