benzyl 3-butylcarbamoyl-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-ylmethylcarbonylamino]propionate

Base Information

Chemical Name:benzyl 3-butylcarbamoyl-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-ylmethylcarbonylamino]propionate
CAS No.:945469-84-1
Molecular Formula:C₃₁H₄₅N₅O₇S
Molecular Weight:631.794
Hs Code.:

Synonyms:benzyl 3-butylcarbamoyl-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-ylmethylcarbonylamino]propionate

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Chemical Property of benzyl 3-butylcarbamoyl-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-ylmethylcarbonylamino]propionate

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Technology Process of benzyl 3-butylcarbamoyl-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-ylmethylcarbonylamino]propionate

There total 8 articles about benzyl 3-butylcarbamoyl-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-ylmethylcarbonylamino]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 945469-84-1
benzyl 3-butylcarbamoyl-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-ylmethylcarbonylamino]propionate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 87.5 percent / 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / ethyl acetate / cooling

2.1: 84.7 percent / NaOH / methanol; H₂O / 1 h / 20 °C

3.1: triethylamine; 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / CH₂Cl₂

3.2: 84 percent / methanol / CH₂Cl₂ / 0.08 h / 20 °C

4.1: N-methylmorpholine / dimethylformamide / -30 °C

5.1: 1.15 g / dimethylformamide / cooling

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1080/00908320701230117

Reference yield:

: 878010-66-3
ethyl 2-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-yl]acetate

: 945469-84-1
benzyl 3-butylcarbamoyl-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-ylmethylcarbonylamino]propionate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 84.7 percent / NaOH / methanol; H₂O / 1 h / 20 °C

2.1: triethylamine; 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / CH₂Cl₂

2.2: 84 percent / methanol / CH₂Cl₂ / 0.08 h / 20 °C

3.1: N-methylmorpholine / dimethylformamide / -30 °C

4.1: 1.15 g / dimethylformamide / cooling

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1080/00908320701230117

Reference yield:

: C₁₄H₂₁NO₄Si*HCl

: 945469-84-1
benzyl 3-butylcarbamoyl-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-ylmethylcarbonylamino]propionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / CH₂Cl₂

1.2: 84 percent / methanol / CH₂Cl₂ / 0.08 h / 20 °C

2.1: N-methylmorpholine / dimethylformamide / -30 °C

3.1: 1.15 g / dimethylformamide / cooling

With 4-methyl-morpholine; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/00908320701230117