Technology Process of tert-butyl 2-(1-(4-bromophenyl)piperidin-4-yloxy)acetate
There total 5 articles about tert-butyl 2-(1-(4-bromophenyl)piperidin-4-yloxy)acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutylammomium bromide; sodium hydroxide;
In
water; toluene;
at 0 - 20 ℃;
for 17h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / water; dimethyl sulfoxide / 4 h / 100 °C
2.1: hydrogen; palladium 10% on activated carbon / 20 °C
3.1: hydrogen bromide; sodium nitrite / water / 0.5 h / 0 °C
3.2: 2 h / Reflux
4.1: sodium hydroxide; tetrabutylammomium bromide / water; toluene / 17 h / 0 - 20 °C
With
palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen bromide; hydrogen; potassium carbonate; sodium hydroxide; sodium nitrite;
In
water; dimethyl sulfoxide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / water; dimethyl sulfoxide / 4 h / 100 °C
2.1: hydrogen; palladium 10% on activated carbon / 20 °C
3.1: hydrogen bromide; sodium nitrite / water / 0.5 h / 0 °C
3.2: 2 h / Reflux
4.1: sodium hydroxide; tetrabutylammomium bromide / water; toluene / 17 h / 0 - 20 °C
With
palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen bromide; hydrogen; potassium carbonate; sodium hydroxide; sodium nitrite;
In
water; dimethyl sulfoxide; toluene;
